Charoenlarp Pornkawee, Rajendran Arun Kumar, Iseki Sachiko
Section of Molecular Craniofacial Embryology, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549 Japan.
Inflamm Regen. 2017 Aug 1;37:10. doi: 10.1186/s41232-017-0043-8. eCollection 2017.
Bone is a metabolically active organ that undergoes continuous remodeling throughout life. However, many complex skeletal defects such as large traumatic bone defects or extensive bone loss after tumor resection may cause failure of bone healing. Effective therapies for these conditions typically employ combinations of cells, scaffolds, and bioactive factors. In this review, we pay attention to one of the three factors required for regeneration of bone, bioactive factors, especially the fibroblast growth factor (FGF) family. This family is composed of 22 members and associated with various biological functions including skeletal formation. Based on the phenotypes of genetically modified mice and spatio-temporal expression levels during bone fracture healing, FGF2, FGF9, and FGF18 are regarded as possible candidates useful for bone regeneration. The role of these candidate FGFs in bone regeneration is also discussed in this review.
骨骼是一个代谢活跃的器官，在一生中不断进行重塑。然而，许多复杂的骨骼缺陷，如大型创伤性骨缺损或肿瘤切除后的广泛骨质流失，可能导致骨愈合失败。针对这些情况的有效治疗方法通常采用细胞、支架和生物活性因子的组合。在本综述中，我们关注骨再生所需的三个因素之一，即生物活性因子，尤其是成纤维细胞生长因子（FGF）家族。该家族由22个成员组成，并与包括骨骼形成在内的各种生物学功能相关。基于基因修饰小鼠的表型以及骨折愈合过程中的时空表达水平，FGF2、FGF9和FGF18被认为是对骨再生有用的可能候选因子。本综述还讨论了这些候选FGF在骨再生中的作用。
