子宫肌瘤——有什么新进展？
Uterine fibroids - what's new?
作者信息
Williams Alistair R W
机构信息
Department of Pathology, Royal Infirmary of Edinburgh, University of Edinburgh, 51 Little France Crescent, Edinburgh, EH16 4SA, UK.
出版信息
F1000Res. 2017 Dec 7;6:2109. doi: 10.12688/f1000research.12172.1. eCollection 2017.
Abstract
Uterine fibroids are the commonest benign tumours of women and affect all races with a cumulative lifetime risk of around 70%. Despite their high prevalence and the heavy economic burden of treatment, fibroids have received remarkably little attention compared to common female malignant tumours. This article reviews recent progress in understanding the biological nature of fibroids, their life cycle and their molecular genetic origins. Recent progress in surgical and interventional management is briefly reviewed, and medical management options, including treatment with selective progesterone receptor modulators, are also discussed.
摘要
子宫肌瘤是女性最常见的良性肿瘤，影响所有种族，终生累积风险约为70%。尽管其发病率高且治疗负担沉重，但与常见的女性恶性肿瘤相比，子宫肌瘤受到的关注却少得多。本文综述了在了解子宫肌瘤的生物学特性、生命周期及其分子遗传学起源方面的最新进展。简要回顾了手术和介入治疗管理方面的最新进展，并讨论了包括使用选择性孕激素受体调节剂治疗在内的药物治疗选择。
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