视神经压迫：筛板及跨筛板压力的作用
Optic nerve compression: the role of the lamina cribrosa and translaminar pressure.
作者信息
Romano Mario R, Cennamo Gilda, Breve Maria Angelica, Piedepalumbo Michela, Iovino Claudio, Velotti Nunzio, Cennamo Giovanni
机构信息
Department of Biomedical Sciences, Humanitas University, Milan 20089, Italy.
Department of Public Health, University of Naples Federico II, Naples 80131, Italy.
出版信息
Int J Ophthalmol. 2017 Dec 18;10(12):1883-1888. doi: 10.18240/ijo.2017.12.15. eCollection 2017.
AIM
To describe the morphological changes of the lamina cribrosa (LC) in patients with optic nerve compression.
METHODS
Cross-sectional study. Twenty eyes with optic nerve compression, affected by Graves' ophthalmopathy (GO) were compared with 18 refractive error-matched healthy eyes. The following examinations were performed: best-corrected visual acuity (BCVA), intraocular pressure, optic nerve echography, visual field, SD-OCT including the retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), and LC thickness and extent.
RESULTS
A-scan revealed significant differences in the subarachnoid space (SAS) between the affected and control groups. LC thickness and LC area were 233 µm (SD 23) and 0.41 mm (SD 0.19), respectively. Average GCC thickness (=0.0005), LC thickness (=0.001), MD (=0.001) and PSD (=0.001) differed significantly between the two groups; whereas LC area (=0.2) and average RFNL (=0.1) did not.
CONCLUSION
Optic nerve compression reduces the SAS thereby altering the morphology of LC thickness and causing GCC damage.
目的
描述视神经受压患者筛板（LC）的形态学变化。
方法
横断面研究。将20只受格雷夫斯眼病（GO）影响的视神经受压眼与18只屈光不正匹配的健康眼进行比较。进行了以下检查：最佳矫正视力（BCVA）、眼压、视神经超声检查、视野、包括视网膜神经纤维层（RNFL）、神经节细胞复合体（GCC）以及LC厚度和范围的SD-OCT。
结果
A超显示患侧组与对照组之间蛛网膜下腔（SAS）存在显著差异。LC厚度和LC面积分别为233 µm（标准差23）和0.41 mm（标准差0.19）。两组之间平均GCC厚度（=0.0005）、LC厚度（=0.001）、平均偏差（MD）（=0.001）和模式标准差（PSD）（=0.001）存在显著差异；而LC面积（=0.2）和平均RNFL（=0.1）无显著差异。
结论
视神经受压会减小SAS，从而改变LC厚度的形态并导致GCC损伤。
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