Ergen Abdullah, Yılmaz Tuğan Büşra
Department of Ophthalmology, Kocaeli University, Kocaeli, Turkey.
Sci Rep. 2025 Jul 2;15(1):22981. doi: 10.1038/s41598-025-06584-8.
This study aims to evaluate lamina cribrosa (LC) parameters, macular ganglion cell layer thickness (GCLT) and peripapillary retina nerve fiber layer thickness (RNFLT) in Graves' Ophthalmopathy (GO) patients using spectral domain optical coherence tomography (SD-OCT). Seventy GO patients and 70 healthy subjects were included in the study. LC thickness (LCT), LC depth (LCD), LC curvature depth (LCCD), LC curvature index (LCCI) measurements, peripapillary RNFLT and macular GCLT were evaluated with SD-OCT, and proptosis was evaluated with Hertel exophthalmometer. Clinical activity was assessed using the clinical activity score (CAS). Disease severity was evaluated according to the European Group on Graves Orbitopathy (EUGOGO) stage. SD-OCT revealed significant differences in the LC morphology between the affected and control groups. LCT was significantly decreased in the GO group (236.7 ± 37.1 μm) compared to the control group (276.1 ± 36.3 μm) (p < 0.001). Median LCCD was significantly higher in the patient group [95.5 (80.5-127.5) µm] than in the control group [78 (66-90.25) µm] (p < 0.001). LCCI was 6.08 (4.7-7.5) in the GO group and 4.9 (4.3-5.6) in the control group. The difference between the two groups regarding LCCI was statistically significant (p < 0.001). The mean LCD, central foveal GCLT, peripapillary global RNFLT and central foveal thickness were not significantly different between the two groups (p = 0.124, p = 0.536, p = 0.226 and p = 0.958, respectively).LC morphology may change in patients with GO. LCT, LCCI and LCCD showed a good ability to differentiate GO from healthy controls. Therefore, they can be used as supporting parameters for diagnosis.
本研究旨在利用光谱域光学相干断层扫描（SD-OCT）评估格雷夫斯眼病（GO）患者的筛板（LC）参数、黄斑神经节细胞层厚度（GCLT）和视乳头周围视网膜神经纤维层厚度（RNFLT）。本研究纳入了70例GO患者和70名健康受试者。使用SD-OCT评估LC厚度（LCT）、LC深度（LCD）、LC曲率深度（LCCD）、LC曲率指数（LCCI），使用Hertel眼球突出计评估眼球突出度。采用临床活动评分（CAS）评估临床活动度。根据欧洲格雷夫斯眼眶病研究组（EUGOGO）分期评估疾病严重程度。SD-OCT显示，患病组与对照组的LC形态存在显著差异。与对照组（276.1±36.3μm）相比，GO组的LCT显著降低（236.7±37.1μm）（p<0.001）。患者组的LCCD中位数[95.5（80.5-127.5）μm]显著高于对照组[78（66-90.25）μm]（p<0.001）。GO组的LCCI为6.08（4.7-7.5），对照组为4.9（4.3-5.6）。两组之间LCCI的差异具有统计学意义（p<0.001）。两组之间的平均LCD、中央凹GCLT、视乳头周围整体RNFLT和中央凹厚度无显著差异（分别为p=0.124、p=0.536、p=0.226和p=0.958）。GO患者的LC形态可能会发生变化。LCT、LCCI和LCCD在区分GO与健康对照方面表现出良好的能力。因此，它们可作为诊断的辅助参数。
