Fosmo Andreas L, Skraastad Øyvind B
Division of Physiology, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Front Cardiovasc Med. 2017 Dec 5;4:75. doi: 10.3389/fcvm.2017.00075. eCollection 2017.
Potassium channels play a pivotal role in the regulation of excitability in cells such as neurons, cardiac myocytes, and vascular smooth muscle cells. The KCNQ (Kv7) family of voltage-activated K channels hyperpolarizes the cell and stabilizes the membrane potential. Here, we outline how Kv7 channel activity may contribute to the development of the cardiovascular risk factors such as hypertension, diabetes, and obesity. Questions and hypotheses regarding previous and future research have been raised. Alterations in the Kv7 channel may contribute to the development of cardiovascular disease (CVD). Pharmacological modification of Kv7 channels may represent a possible treatment for CVD in the future.
钾通道在调节神经元、心肌细胞和血管平滑肌细胞等细胞的兴奋性方面起着关键作用。电压激活钾通道的KCNQ（Kv7）家族使细胞超极化并稳定膜电位。在此，我们概述了Kv7通道活性可能如何促成高血压、糖尿病和肥胖等心血管危险因素的发展。我们提出了关于既往和未来研究的问题及假设。Kv7通道的改变可能促成心血管疾病（CVD）的发展。对Kv7通道进行药理学修饰可能代表着未来治疗CVD的一种可能方法。
