Ding Yue, Sun Xue, Shan Peng-Fei
Department of Endocrinology and Metabolism, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Department of International Health Care Center, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Biomed Res Int. 2017;2017:4080364. doi: 10.1155/2017/4080364. Epub 2017 Feb 12.
Cardiovascular disease (CVD) is the major macrovascular complication of diabetes mellitus. Recently, although CVD morbidity and mortality have decreased as a result of comprehensive control of CVD risk factors, CVD remains the leading cause of death of patients with diabetes in many countries, indicating the potential underlying pathophysiological mechanisms. MicroRNAs are a class of noncoding, single-stranded RNA molecules that are involved in -cell function, insulin secretion, insulin resistance, skeletal muscle, and adipose tissue and which play an important role in glucose homeostasis and the pathogenesis of diabetic complications. Here, we review recent progress in research on microRNAs in endothelial cell and vascular smooth muscle cell dysfunction, macrophage and platelet activation, lipid metabolism abnormality, and cardiomyocyte repolarization in diabetes mellitus. We also review the progress of microRNAs as potential biomarkers and therapeutic targets of CVD in patients with diabetes.
心血管疾病（CVD）是糖尿病的主要大血管并发症。近来，尽管由于对CVD危险因素的综合控制，CVD的发病率和死亡率有所下降，但在许多国家，CVD仍是糖尿病患者的主要死因，这表明潜在的病理生理机制。微小RNA是一类非编码单链RNA分子，参与β细胞功能、胰岛素分泌、胰岛素抵抗、骨骼肌和脂肪组织，在葡萄糖稳态及糖尿病并发症的发病机制中起重要作用。在此，我们综述了微小RNA在糖尿病患者内皮细胞和血管平滑肌细胞功能障碍、巨噬细胞和血小板活化、脂质代谢异常及心肌细胞复极化方面的研究进展。我们还综述了微小RNA作为糖尿病患者CVD潜在生物标志物和治疗靶点的研究进展。
