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胶质母细胞瘤中的凋亡信号通路及其治疗意义。

Apoptotic Signaling Pathways in Glioblastoma and Therapeutic Implications.

机构信息

Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.

Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.

出版信息

Biomed Res Int. 2017;2017:7403747. doi: 10.1155/2017/7403747. Epub 2017 Nov 12.

DOI:10.1155/2017/7403747
PMID:29259986
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5702396/
Abstract

Glioblastoma multiforme (GBM) is the most hostile type of brain cancer. Its aggressiveness is due to increased invasion, migration, proliferation, angiogenesis, and a decreased apoptosis. In this review, we discuss the role of key regulators of apoptosis in GBM and glioblastoma stem cells. Given their importance in the etiology and pathogenesis of GBM, these signaling molecules may represent potential therapeutic targets.

摘要

多形性胶质母细胞瘤（GBM）是最具侵袭性的脑癌。其侵袭性归因于细胞的过度侵袭、迁移、增殖、血管生成，以及细胞凋亡减少。在这篇综述中，我们讨论了凋亡关键调节因子在 GBM 和胶质母细胞瘤干细胞中的作用。鉴于它们在 GBM 的病因和发病机制中的重要性，这些信号分子可能代表潜在的治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b905/5702396/50128b5de583/BMRI2017-7403747.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b905/5702396/156145e0584b/BMRI2017-7403747.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b905/5702396/50128b5de583/BMRI2017-7403747.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b905/5702396/156145e0584b/BMRI2017-7403747.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b905/5702396/50128b5de583/BMRI2017-7403747.002.jpg

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Expression of CD133 and CD44 in glioblastoma stem cells correlates with cell proliferation, phenotype stability and intra-tumor heterogeneity.
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J Proteome Res. 2025 Jul 4;24(7):3610-3624. doi: 10.1021/acs.jproteome.5c00199. Epub 2025 Jun 15.
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Doxorubicin and NFL-TBS.40-63 peptide loaded gold nanoparticles as a multimodal therapy of glioblastoma.阿霉素和负载NFL-TBS.40-63肽的金纳米颗粒作为胶质母细胞瘤的多模态治疗方法。
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Mol Neurodegener. 2025 Jan 18;20(1):7. doi: 10.1186/s13024-025-00801-8.
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Phytother Res. 2025 Feb;39(2):776-788. doi: 10.1002/ptr.8413. Epub 2024 Dec 13.
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