癌症相关性视网膜病变治疗后光学相干断层扫描显示外层视网膜分层的恢复情况
Recovery of outer retinal laminations on optical coherence tomography after treatment of cancer associated retinopathy.
作者信息
Irizarry Francisco J, Kopplin Laura J, Salek Sherveen S, Adamus Grazyna, Saleh Mohamed, Biggee Kristin, Lin Phoebe, Rosenbaum James T
机构信息
Ponce Health Science University, 388 Zona Ind. Reparada 2, Ponce 00716, Puerto Rico.
Casey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Boulevard, Portland, OR 97239, USA.
出版信息
Am J Ophthalmol Case Rep. 2017 Sep 1;8:11-13. doi: 10.1016/j.ajoc.2017.08.001. eCollection 2017 Dec.
PURPOSE
To report novel optical coherence tomography findings in a case of anti-α-enolase cancer associated retinopathy.
OBSERVATIONS
An elderly female presented with bilateral decreased vision and a recent diagnosis of ovarian carcinoma. Optical coherence tomography demonstrated bilateral loss of outer retinal structures and macular edema. Serum testing found antibodies against α-enolase and 82-84 kDa proteins. Outer retinal structures showed recovery, macular edema resolved and repeat anti-retinal antibody testing became negative following cancer therapy and topical difluprednate treatment.
CONCLUSIONS AND IMPORTANCE
Cancer associated retinopathy is a paraneoplastic disease that results in damage to retinal structures through an autoimmune response. The damage is generally considered to be irreversible; however, in rare cases, such as observed here, retinal structures may demonstrate recovery after treatment.
目的
报告1例抗α-烯醇化酶癌症相关性视网膜病变的新型光学相干断层扫描结果。
观察结果
一名老年女性出现双侧视力下降，近期被诊断为卵巢癌。光学相干断层扫描显示双侧视网膜外层结构丧失和黄斑水肿。血清检测发现抗α-烯醇化酶和82 - 84 kDa蛋白的抗体。在癌症治疗和局部应用双氟泼尼酯治疗后，视网膜外层结构恢复，黄斑水肿消退，重复的抗视网膜抗体检测变为阴性。
结论与意义
癌症相关性视网膜病变是一种副肿瘤性疾病，通过自身免疫反应导致视网膜结构损伤。一般认为这种损伤是不可逆的；然而，在罕见情况下，如此处观察到的，视网膜结构在治疗后可能会恢复。
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