Department of Ophthalmology, University of Virginia Health System, Charlottesville, Virginia, USA.
Am J Ophthalmol. 2012 Apr;153(4):750-6, 756.e1. doi: 10.1016/j.ajo.2011.09.012. Epub 2012 Jan 14.
To report optical coherence tomography (OCT) features of patients with autoimmune retinopathy.
Consecutive case series.
Eight patients who presented with unexplained loss of central vision, visual field defects, and/or photopsia were diagnosed with autoimmune retinopathy based on clinical features, electroretinogram (ERG) findings, and serum antiretinal antibody analysis. All patients underwent OCT testing of the macula and nerve fiber layer (NFL).
Outer retinal abnormalities and/or decreased macular thickness on OCT were seen in all patients. Macular OCT showed reduced central macular and foveal thicknesses in 6 patients (mean thickness 143±30 μm and 131±29 μm respectively). In all but 1 patient, loss of the photoreceptor layer or disruption of the photoreceptor outer and inner segment junction was noted. Three patients showed only mild to moderate focal NFL loss.
Retinal atrophy and reduced macular thickness on OCT are predominant features in patients with autoimmune retinopathy. OCT provides objective measures of retinal damage and may offer clues toward understanding the mechanism of visual dysfunction and the diagnosis of autoimmune retinopathy.
报告自身免疫性视网膜病变患者的光学相干断层扫描（OCT）特征。
连续病例系列。
8 名患者因不明原因的中心视力丧失、视野缺损和/或闪光而就诊，根据临床特征、视网膜电图（ERG）发现和血清抗视网膜抗体分析诊断为自身免疫性视网膜病变。所有患者均行黄斑和神经纤维层（NFL）OCT 检查。
所有患者的外视网膜异常和/或黄斑厚度变薄。黄斑 OCT 显示 6 例患者的中央黄斑和中心凹厚度减少（平均厚度分别为 143±30μm 和 131±29μm）。除 1 例患者外，所有患者均出现光感受器层缺失或光感受器外节和内节连接中断。3 例患者仅表现为轻度至中度局灶性 NFL 丢失。
OCT 显示自身免疫性视网膜病变患者的视网膜萎缩和黄斑厚度变薄是主要特征。OCT 提供了视网膜损伤的客观测量指标，并可能有助于理解视觉功能障碍的机制和自身免疫性视网膜病变的诊断。
