Ngene Samuel O, Adedokun Babatunde, Adejumo Prisca, Olopade Olufunmilayo
Department of Epidemiology and Medical Statistics, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Department of Nursing, University of Ibadan, Ibadan, Nigeria.
J Genet Couns. 2018 Aug;27(4):863-873. doi: 10.1007/s10897-017-0194-4. Epub 2017 Dec 19.
Genetic testing services for breast cancer are well established in developed countries compared to African populations that bear a disproportionate burden of breast cancer (BC). The objective of this study is to examine the knowledge of professional Nigerian women about BC genetics and their intentions to utilize genetic testing services when it is made available in Nigeria. In this study, 165 lecturers and 189 bankers were recruited and studied using a validated self-administered questionnaire. The respondents' mean age was 34.9 years (SD = 10.9), 6.5% had family history of BC, and 84.7% had limited knowledge of breast cancer genetics. The proportion of women with genetic testing intentions for breast cancer was 87.3%. Health care access (OR = 2.35, 95% CI, 1.07-5.13), religion (OR = 3.51, 95% CI, 1.03-11.92), and perceived personal risk if a close relative had breast cancer (OR = 2.31, 95% CI, 1.05-5.08) independently predicted testing intentions. The genetic testing intentions for BC were high despite limited knowledge about breast cancer genetics. Promotion of BC genetics education as well as efforts to make BC genetic testing services available in Nigeria at reduced cost remains essential.
与承担着不成比例的乳腺癌负担的非洲人群相比，发达国家的乳腺癌基因检测服务已经很成熟。本研究的目的是调查尼日利亚职业女性对乳腺癌遗传学的了解程度，以及在尼日利亚提供基因检测服务时她们使用该服务的意愿。在本研究中，招募了165名讲师和189名银行职员，并使用经过验证的自填式问卷进行研究。受访者的平均年龄为34.9岁（标准差=10.9），6.5%有乳腺癌家族史，84.7%对乳腺癌遗传学知识了解有限。有乳腺癌基因检测意愿的女性比例为87.3%。医疗保健可及性（比值比=2.35，95%置信区间，1.07 - 5.13）、宗教信仰（比值比=3.51，95%置信区间，1.03 - 11.92）以及如果近亲患有乳腺癌时感知到的个人风险（比值比=2.31，95%置信区间，1.05 - 5.08）独立预测了检测意愿。尽管对乳腺癌遗传学知识了解有限，但对乳腺癌基因检测的意愿仍然很高。在尼日利亚推广乳腺癌遗传学教育以及努力以降低成本提供乳腺癌基因检测服务仍然至关重要。
