哪些因素影响女性进行癌症基因检测的决定？
What Factors Impact upon a Woman's Decision to Undertake Genetic Cancer Testing?
机构信息
North Metropolitan Health Service, Western Australian Department of Health , Perth, WA , Australia ; Institute of Health Research, University of Notre Dame Australia , Fremantle, WA , Australia.
Institute of Health Research, University of Notre Dame Australia , Fremantle, WA , Australia.
出版信息
Front Oncol. 2014 Jan 6;3:325. doi: 10.3389/fonc.2013.00325.
INTRODUCTION
The advent of human genome project has lead to genetic tests that identify high-risk states for certain cancers. Many are privately marketed on the Internet. Despite the availability of tests, limited data has evaluated factors that lead to test uptake. The aim of the present study was to explore the attitudes of a cohort of new mothers toward uptake of a genetic cancer test with a 50% predictive value of cancer.
METHODS
A cross-sectional survey was undertaken. The project targeted women who had recently given birth at an Australian tertiary referral hospital. Women were asked about a theoretical blood test that detected an increased risk for the development of cancer. Attitudes and knowledge questionnaires were completed.
RESULTS
Of 232 consecutive women approached, 32 declined, giving a response rate of 86.2%. Only 63 (31.5%) women stated they would have the test. Absence of religious belief, higher level of education, better knowledge of terms used in genetics, an absence of concern over emotional, employment, and insurance discrimination, and previous acceptance of Down syndrome screening in pregnancy were each associated with significantly higher rate of test uptake in univariate analysis (all p < 0.03). In multivariate analysis, a lack of concern over discrimination and a history of having accepted Down syndrome screening in the previous pregnancy remained significantly associated with test uptake (all p < 0.0001).
CONCLUSION
Concern over discrimination and having made a prior decision to have genetic testing were the principal factors associated with decision-making.
简介
人类基因组计划的出现带来了能够识别某些癌症高危状态的基因检测。许多此类检测在互联网上进行私人营销。尽管有这些检测可供使用，但评估导致检测采用的因素的数据有限。本研究的目的是探讨一组新妈妈对具有 50%癌症预测价值的癌症基因检测的态度。
方法
进行了一项横断面调查。该项目针对的是澳大利亚一家三级转诊医院最近分娩的女性。女性被问及一项理论上可以检测癌症发展风险增加的血液检测。完成了态度和知识问卷。
结果
在 232 名连续接触的女性中，有 32 名拒绝了，应答率为 86.2%。只有 63 名（31.5%）女性表示她们会接受检测。缺乏宗教信仰、较高的教育水平、更好地理解遗传学中使用的术语、不担心情感、就业和保险歧视，以及以前在怀孕期间接受唐氏综合征筛查，这些在单因素分析中都与更高的检测采用率显著相关（均 p<0.03）。在多因素分析中，不担心歧视和以前在怀孕期间接受唐氏综合征筛查的历史与检测采用率显著相关（均 p<0.0001）。
结论
对歧视的关注和以前决定进行基因检测是与决策相关的主要因素。
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