Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, 1143 Budapest, Hungary.
Ceva-Phylaxia Zrt., 1107 Budapest, Hungary.
Viruses. 2017 Dec 20;9(12):393. doi: 10.3390/v9120393.
Porcine parvovirus (PPV) is among the most important infectious agents causing infertility in pigs. Until recently, it was thought that the virus had low genetic variance, and that prevention of its harmful effect on pig fertility could be well-controlled by vaccination. However, at the beginning of the third millennium, field observations raised concerns about the effectiveness of the available vaccines against newly emerging strains. Subsequent investigations radically changed our view on the evolution and immunology of PPV, revealing that the virus is much more diverse than it was earlier anticipated, and that some of the "new" highly virulent isolates cannot be neutralized effectively by antisera raised against "old" PPV vaccine strains. These findings revitalized PPV research that led to significant advancements in the understanding of early and late viral processes during PPV infection. Our review summarizes the recent results of PPV research and aims to give a comprehensive update on the present understanding of PPV biology.
猪细小病毒（PPV）是导致猪不孕的最重要的传染性病原体之一。直到最近，人们还认为该病毒的遗传变异很小，通过疫苗接种可以很好地控制其对猪繁殖力的有害影响。然而，在第三个千年开始时，对现场观察的结果引发了对现有疫苗对新出现的毒株的有效性的关注。随后的调查彻底改变了我们对 PPV 的进化和免疫学的看法，表明该病毒比以前预期的更为多样化，并且一些“新”的高毒力分离株不能被针对“旧”PPV 疫苗株的抗血清有效中和。这些发现重振了 PPV 研究，从而使人们对 PPV 感染过程中的早期和晚期病毒过程有了更深入的了解。我们的综述总结了 PPV 研究的最新结果，旨在全面更新对 PPV 生物学的现有认识。
