猪细小病毒进化的观点
Perspectives on the Evolution of Porcine Parvovirus.
作者信息
Oh Woo-Taek, Kim Ri-Yeon, Nguyen Van-Giap, Chung Hee-Chun, Park Bong-Kyun
机构信息
Department of Veterinary Medicine Virology Lab, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Korea.
Queen's University, Pathology and Molecular Medicine, Kingston, ON 613-343, Canada.
出版信息
Viruses. 2017 Jul 26;9(8):196. doi: 10.3390/v9080196.
Porcine parvovirus (PPV) is one of the main causes of porcine reproductive failure. It is important for swine industries to understand the recent trends in PPV evolution. Previous data show that PPV has two genetic lineages originating in Germany. In this study, two more genetic lineages were defined, one of which was distinctly Asian. Additionally, amino acid substitutions in European strains and Asian strains showed distinct differences in several regions of the gene. The gene of the recent PPV isolate (T142_South Korea) was identical to that of Kresse strain isolated in the USA in 1985, indicating that modern PPV strains now resemble the original strains (Kresse and NADL-2). In this study, we compared strains isolated in the 20th century to recent isolates and confirmed the trend that modern strains are becoming more similar to previous strains.
猪细小病毒（PPV）是猪繁殖障碍的主要原因之一。了解PPV进化的最新趋势对养猪业很重要。先前的数据表明，PPV有两个起源于德国的遗传谱系。在本研究中，又定义了两个遗传谱系，其中一个明显来自亚洲。此外，欧洲毒株和亚洲毒株的氨基酸替换在该基因的几个区域表现出明显差异。最近的PPV分离株（T142_韩国）的基因与1985年在美国分离的Kresse毒株相同，这表明现代PPV毒株现在类似于原始毒株（Kresse和NADL-2）。在本研究中，我们将20世纪分离的毒株与最近的分离株进行了比较，并证实了现代毒株正变得越来越类似于先前毒株的趋势。
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