与系统性红斑狼疮相关的α干扰素本质上并非酸不稳定。
Interferon alpha associated with systemic lupus erythematosus is not intrinsically acid labile.
作者信息
Yee A M, Buyon J P, Yip Y K
机构信息
Department of Microbiology, Sackler Institute of Graduate Biomedical Sciences, New York, New York.
出版信息
J Exp Med. 1989 Mar 1;169(3):987-93. doi: 10.1084/jem.169.3.987.
Abstract
The physicochemical properties of apparently acid-labile IFN-alpha from patients with SLE have been studied. The antigenicity, apparent molecular size, and isoelectric point of SLE IFN-alpha are indistinguishable from those of conventional, previously characterized, acid-stable subspecies of IFN-alpha. However, after partial purification by anion-exchange chromatography, SLE IFN-alpha no longer exhibits acid lability, suggesting that other plasma factor(s) are responsible for the acid lability of SLE IFN-alpha. Addition of SLE plasma, but not normal plasma, to conventional acid-stable IFN-alpha renders the exogenous IFN-alpha acid labile. Preliminary results demonstrate that an acid-dependent IFN-inactivating activity can be partially purified from SLE plasma by anion-exchange chromatography.
摘要
对系统性红斑狼疮（SLE）患者中明显酸不稳定的α干扰素的理化特性进行了研究。SLEα干扰素的抗原性、表观分子大小和等电点与传统的、先前已表征的酸稳定α干扰素亚型无法区分。然而，通过阴离子交换色谱法进行部分纯化后，SLEα干扰素不再表现出酸不稳定性，这表明其他血浆因子对SLEα干扰素的酸不稳定性负责。将SLE血浆而非正常血浆添加到传统的酸稳定α干扰素中，会使外源性α干扰素变得酸不稳定。初步结果表明，一种酸依赖性干扰素灭活活性可以通过阴离子交换色谱法从SLE血浆中部分纯化出来。
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本文引用的文献
1
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Arthritis Rheum. 1982 Nov;25(11):1271-7. doi: 10.1002/art.1780251101.
2
Acid-labile human leukocyte interferon in homosexual men with Kaposi's sarcoma and lymphadenopathy.患有卡波西肉瘤和淋巴结病的同性恋男性体内的酸不稳定型人白细胞干扰素
J Infect Dis. 1982 Oct;146(4):451-9. doi: 10.1093/infdis/146.4.451.
3
Acid labile alpha-interferon in sera and synovial fluids from patients with juvenile arthritis.青少年关节炎患者血清和滑液中的酸不稳定α干扰素。
Arthritis Rheum. 1984 May;27(5):582-5. doi: 10.1002/art.1780270517.
4
5
Immunochemical analysis of Micrococcus lysodeikticus (luteus) F1-ATPase and its subunits.
Biochim Biophys Acta. 1983 Aug 31;724(2):230-40. doi: 10.1016/0005-2728(83)90142-1.
6
Antibodies to alpha-interferon in a patient with systemic lupus erythematosus.一名系统性红斑狼疮患者体内的α干扰素抗体。
J Immunol. 1982 Jul;129(1):1-3.
7
Multiple interferons in the circulation of patients with systemic lupus erythematosus and vasculitis.系统性红斑狼疮和血管炎患者循环中的多种干扰素。
Arthritis Rheum. 1982 Apr;25(4):396-400. doi: 10.1002/art.1780250406.
8
Systemic lupus erythematosus: presence in human serum of an unusual acid-labile leukocyte interferon.系统性红斑狼疮：人血清中存在一种异常的酸不稳定白细胞干扰素。
Science. 1982 Apr 23;216(4544):429-31. doi: 10.1126/science.6176024.
9
Interferon inhibits the suppressor T cell response of delayed-type hypersensitivity.
Nature. 1982 Apr 22;296(5859):757-9. doi: 10.1038/296757a0.
10
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Ann N Y Acad Sci. 1980;350:21-32. doi: 10.1111/j.1749-6632.1980.tb20603.x.
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