Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, UT, USA.
Department of Anthropology, Center for the Advanced Study of Human Paleobiology, The George Washington University, Washington DC, USA.
Sci Rep. 2017 Dec 20;7(1):17955. doi: 10.1038/s41598-017-18199-9.
We compared the cranial base of newborn Pax7-deficient and wildtype mice using a computational shape modeling technology called particle-based modeling (PBM). We found systematic differences in the morphology of the basiooccipital bone, including a broadening of the basioccipital bone and an antero-inferior inflection of its posterior edge in the Pax7-deficient mice. We show that the Pax7 cell lineage contributes to the basioccipital bone and that the location of the Pax7 lineage correlates with the morphology most effected by Pax7 deficiency. Our results suggest that the Pax7-deficient mouse may be a suitable model for investigating the genetic control of the location and orientation of the foramen magnum, and changes in the breadth of the basioccipital.
我们使用一种名为基于粒子的建模（PBM）的计算形状建模技术比较了新生 Pax7 缺陷型和野生型小鼠的颅底。我们发现，在 basiooccipital 骨的形态上存在系统差异，包括 basioccipital 骨变宽以及其后缘前下弯曲在 Pax7 缺陷型小鼠中。我们表明，Pax7 细胞谱系有助于 basioccipital 骨的形成，并且 Pax7 谱系的位置与 Pax7 缺陷最相关的形态相关。我们的结果表明，Pax7 缺陷型小鼠可能是研究枕骨大孔位置和方向的遗传控制以及 basioccipital 骨宽度变化的合适模型。
