Kumar Aditi, Blackshear Chad, Subauste Jose S, Esfandiari Nazanene H, Oral Elif Arioglu, Subauste Angela R
Department of Medicine, Division of Endocrinology, University of Mississippi Medical Center, Jackson, Mississippi, 39216.
Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, Mississippi, 39216.
J Endocr Soc. 2017 Mar 22;1(5):460-469. doi: 10.1210/js.2017-00055. eCollection 2017 May 1.
Fatty liver disease is one of the most common forms of chronic liver disease. The renin-angiotensin-aldosterone system has been implicated in the pathogenesis of fatty liver.
Determine the relationship between fatty liver and aldosterone in a large cohort study.
Community-based, observational cohort study of African Americans.
The original Jackson Heart Study cohort enrolled African American participants from the Jackson, Mississippi, metropolitan area in Hinds, Madison, and Rankin Counties.
Our study population consisted of 2507 Jackson Heart Study participants (1625 women and 882 men) who had liver attenuation measured per computed tomography scans, had aldosterone measurements, and were not taking angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, or mineralocorticoid receptor antagonists.
There was no intervention.
Liver attenuation on computed tomography scans.
Univariate regression analysis demonstrated a statistically significant correlation between aldosterone levels and liver attenuation. Each doubling of aldosterone was associated with 1.08 Hounsfield unit decrease (95% confidence interval, 1.47 to -0.69, < 0.001). A multivariable model adjusted for body mass index, age, alcohol intake, and homeostatic model assessment of insulin resistance determined that the association was statistically significant only for women.
Our data demonstrate a positive association between aldosterone levels and fatty liver in African American women.
脂肪性肝病是最常见的慢性肝病形式之一。肾素-血管紧张素-醛固酮系统与脂肪性肝病的发病机制有关。
在一项大型队列研究中确定脂肪性肝病与醛固酮之间的关系。
基于社区的非裔美国人观察性队列研究。
最初的杰克逊心脏研究队列招募了来自密西西比州杰克逊市大都市地区辛兹县、麦迪逊县和兰金县的非裔美国参与者。
我们的研究人群包括2507名杰克逊心脏研究参与者（1625名女性和882名男性），他们通过计算机断层扫描测量了肝脏衰减，进行了醛固酮测量，且未服用血管紧张素转换酶抑制剂、血管紧张素受体阻滞剂或盐皮质激素受体拮抗剂。
无干预。
计算机断层扫描上的肝脏衰减。
单变量回归分析显示醛固酮水平与肝脏衰减之间存在统计学显著相关性。醛固酮每增加一倍，肝脏衰减就会降低1.08亨氏单位（95%置信区间为1.47至-0.69，P<0.001）。在对体重指数、年龄、酒精摄入量和胰岛素抵抗的稳态模型评估进行调整的多变量模型中，该关联仅在女性中具有统计学显著性。
我们的数据表明非裔美国女性的醛固酮水平与脂肪性肝病之间存在正相关。
