Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, E-Institute of Shanghai Universities, Shanghai 200025, China; Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, E-Institute of Shanghai Universities, Shanghai 200025, China; Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Clin Nutr. 2014 Jun;33(3):521-7. doi: 10.1016/j.clnu.2013.07.010. Epub 2013 Jul 17.
BACKGROUND & AIMS: Evidence has suggested that low serum potassium concentration or low dietary potassium intake can result in many metabolic disorders. Our objective was to evaluate the association between serum potassium level and risk of prevalent metabolic syndrome.
We conducted a cross-sectional study in 10,341 participants aged 40 years or older. Metabolic syndrome was defined according to guidelines from the National Cholesterol Education Program with modification.
The prevalence rate of metabolic syndrome was 51.7% in participants with hypokalemia and 37.7% in those with normokalemia. With the reduction of serum potassium quartiles, participants were tended to have higher level of triglycerides and uric acid, lower level of high-density lipoprotein cholesterol (HDL-C), larger waist circumference and more severe insulin resistance. Serum potassium level significantly decreased with the increasing number of metabolic syndrome components. Compared with subjects in the highest quartile of serum potassium level, multivariate adjusted odds ratios for prevalent metabolic syndrome in the lowest quartile was 1.48 (95% confidence interval, 1.16-1.87). Moreover, compared with subjects without central obesity, hypertriglyceridemia, low HDL-C and elevated fasting plasma glucose, those with each of these metabolic syndrome components have lower level of serum potassium after adjusted for age and sex.
Low serum potassium level significantly associated with prevalence of metabolic syndrome in middle-aged and elderly Chinese.
有证据表明，血清钾浓度低或钾摄入不足可能导致多种代谢紊乱。我们的目的是评估血清钾水平与常见代谢综合征风险之间的关系。
我们对 10341 名年龄在 40 岁及以上的参与者进行了横断面研究。代谢综合征的定义根据国家胆固醇教育计划指南进行了修改。
低钾血症患者代谢综合征的患病率为 51.7%，正常血钾患者为 37.7%。随着血清钾四分位的降低，参与者的甘油三酯和尿酸水平升高，高密度脂蛋白胆固醇（HDL-C）水平降低，腰围增大，胰岛素抵抗更严重。血清钾水平随代谢综合征成分数量的增加而显著降低。与血清钾水平最高四分位的受试者相比，血清钾水平最低四分位的受试者发生常见代谢综合征的多变量校正比值比为 1.48（95%置信区间，1.16-1.87）。此外，与无中心性肥胖、高三酰甘油血症、低高密度脂蛋白胆固醇和空腹血糖升高的受试者相比，调整年龄和性别后，具有这些代谢综合征成分的受试者的血清钾水平较低。
血清钾水平低与中国中老年人群代谢综合征的患病率显著相关。
