鉴定葡萄牙念珠菌为人类机会性酵母菌。
Identification of Candida lusitaniae as an opportunistic yeast in humans.
作者信息
Holzschu D L, Presley H L, Miranda M, Phaff H J
出版信息
J Clin Microbiol. 1979 Aug;10(2):202-5. doi: 10.1128/jcm.10.2.202-205.1979.
Abstract
Four yeast strains, causally associated with infection in a patient with acute myelogenous leukemia, were identified by standard methods currently used in yeast taxonomy as representatives of Candida lusitania van Uden et do Carmo-Sousa. Because this species has not been recognized previously as an opportunistic yeast in humans, molecular taxonomic methods were applied to confirm its identity. The nuclear deoxyribonucleic acid (DNA) base composition of two clinical isolates was shown to be 45.1 mol% guanine plus cytosine as compared to 44.7 mol% guanine plus cytosine for the type strain of this species. DNA/DNA reassociation experiments revealed more than 95% complementarity between the DNAs from the clinical isolates and that of the type strain of C. lusitaniae, thus confirming their classification by conventional taxonomy. A key is provided to differentiate C. lusitaniae from two phenotypically similar Candida species.
摘要
通过目前酵母分类学中使用的标准方法，从一名急性髓性白血病患者的感染病例中鉴定出四株酵母菌株，它们被确定为葡萄牙念珠菌（Candida lusitania van Uden et do Carmo-Sousa）的代表菌株。由于该菌种此前未被认为是人类的机会性酵母，因此应用分子分类学方法来确认其身份。结果显示，两株临床分离株的核脱氧核糖核酸（DNA）碱基组成为鸟嘌呤加胞嘧啶占45.1摩尔%，而该菌种模式菌株的这一比例为44.7摩尔%。DNA/DNA重缔合实验表明，临床分离株的DNA与葡萄牙念珠菌模式菌株的DNA之间的互补性超过95%，从而通过传统分类学证实了它们的分类。本文提供了一个鉴别葡萄牙念珠菌与另外两种表型相似的念珠菌属菌种的检索表。
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