感染人类的葡萄牙念珠菌对两性霉素B耐药性的产生
Development of resistance to amphotericin B in Candida lusitaniae infecting a human.
作者信息
Pappagianis D, Collins M S, Hector R, Remington J
出版信息
Antimicrob Agents Chemother. 1979 Aug;16(2):123-6. doi: 10.1128/AAC.16.2.123.
Abstract
Candida lusitaniae associated with infection in a patient with acute myelogenous leukemia developed resistance to amphotericin B during systemic treatment of the patient. The organism, when isolated initially, was inhibited by 0.31 mug of amphotericin B per ml in yeast nitrogen base agar, but when isolated (20 days later) just antemortem and postmortem, required 100 and 50 mug/ml, respectively, for complete inhibition at 48 h.
摘要
在一名急性髓性白血病患者感染过程中分离出的葡萄牙念珠菌，在该患者的全身治疗期间对两性霉素B产生了耐药性。最初分离出的该菌株，在酵母氮源琼脂中每毫升被0.31微克两性霉素B抑制，但在（20天后）临死前和死后分离时，在48小时完全抑制分别需要100微克/毫升和50微克/毫升。
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