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从艺术到科学:医学的一种新认识论地位?关于个性化医疗的期望。

From art to science: a new epistemological status for medicine? On expectations regarding personalized medicine.

作者信息

Wiesing Urban

机构信息

Institute for Ethics and the History of Medicine, University of Tübingen, Gartenstr. 47, 72074, Tübingen, Germany.

出版信息

Med Health Care Philos. 2018 Dec;21(4):457-466. doi: 10.1007/s11019-017-9820-z.

DOI:10.1007/s11019-017-9820-z
PMID:29264706
Abstract

Personalized medicine plays an important role in the development of current medicine. Among the numerous statements regarding the future of personalized medicine, some can be found that accord medicine a new scientific status. Medicine will be transformed from an art to a science due to personalized medicine. This prognosis is supported by references to models of historical developments. The article examines what is meant by this prognosis, what consequences it entails, and how feasible it is. It refers to the long tradition of epistemological thinking in medicine and the use of historical models for the development of medicine. The possible answers to the question "art or science" are systematized with respect to the core question about the relationship between knowledge and action. The prediction for medicine to develop from an 'empirical healing art' to a 'rational, molecular science' is nonsensical from an epistemological point of view. The historical models employed to substantiate the development of personalized medicine are questionable.

摘要

个性化医疗在当前医学发展中发挥着重要作用。在众多关于个性化医疗未来的表述中,可以发现一些赋予医学新科学地位的观点。由于个性化医疗,医学将从一门艺术转变为一门科学。这一预测得到了对历史发展模式的引用支持。本文探讨了这一预测意味着什么、它会带来哪些后果以及其可行性如何。它涉及医学中认识论思维的悠久传统以及历史模式在医学发展中的运用。关于“艺术还是科学”这一问题的可能答案,是围绕知识与行动之间关系的核心问题进行系统化梳理的。从认识论角度来看,医学从“经验性治疗艺术”发展为“理性的分子科学”这一预测是荒谬的。用于证实个性化医疗发展的历史模式是值得怀疑的。

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引用本文的文献

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Precision medicine and monoclonal antibodies: breach of promise?精准医学与单克隆抗体:承诺破灭?
Croat Med J. 2019 Jun 13;60(3):284-289. doi: 10.3325/cmj.2019.60.284.
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Theranostics: is it really a revolution? Evaluating a new term in medicine.治疗诊断学:它真的是一场革命吗?评估医学中的一个新术语。
Med Health Care Philos. 2019 Dec;22(4):593-597. doi: 10.1007/s11019-019-09898-3.
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Precision in health care.医疗保健中的精准性。

本文引用的文献

1
Decision Tools to Improve Personalized Care in Cardiovascular Disease: Moving the Art of Medicine Toward Science.改善心血管疾病个性化护理的决策工具:将医学艺术推向科学。
Circulation. 2017 Mar 21;135(12):1097-1100. doi: 10.1161/CIRCULATIONAHA.116.024247.
2
Between hype and hope: What is really at stake with personalized medicine?在炒作与希望之间:精准医疗真正面临的风险是什么?
Med Health Care Philos. 2016 Sep;19(3):423-30. doi: 10.1007/s11019-016-9697-2.
3
Seven Questions for Personalized Medicine.个性化医疗的七个问题。
Med Health Care Philos. 2018 Dec;21(4):441-442. doi: 10.1007/s11019-018-9870-x.
JAMA. 2015 Sep 8;314(10):999-1000. doi: 10.1001/jama.2015.7725.
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Palliative Oncologists: Specialists in the Science and Art of Patient Care.姑息肿瘤学家:患者护理科学与艺术领域的专家。
J Clin Oncol. 2015 Jul 10;33(20):2314-7. doi: 10.1200/JCO.2014.60.3274. Epub 2015 Apr 27.
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What is personalized medicine: sharpening a vague term based on a systematic literature review.什么是个性化医学:基于系统文献回顾来明晰一个模糊的术语。
BMC Med Ethics. 2013 Dec 21;14:55. doi: 10.1186/1472-6939-14-55.
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[Personalized medicine in oncology: one drug, one biomarker].肿瘤学中的个性化医疗:一种药物,一种生物标志物
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Care of the dying patient: art or science?
BMJ. 2013 Aug 14;347:f5023. doi: 10.1136/bmj.f5023.
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Balancing personalized medicine and personalized care.平衡个性化医疗和个性化护理。
Acad Med. 2013 Mar;88(3):309-13. doi: 10.1097/ACM.0b013e3182806345.
9
From art to applied science.从艺术到应用科学。
Isis. 2012 Sep;103(3):555-63. doi: 10.1086/667979.
10
Personalizing medicine: futures present and past.个性化医疗:现在和过去的未来。
Soc Sci Med. 2012 Nov;75(10):1721-8. doi: 10.1016/j.socscimed.2012.07.031. Epub 2012 Aug 4.