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石墨烯片的一锅法剥离、功能化及尺寸调控:用于生物医学应用的高效体系。

One-pot exfoliation, functionalization, and size manipulation of graphene sheets: efficient system for biomedical applications.

作者信息

Bani Farhad, Bodaghi Ali, Dadkhah Abbas, Movahedi Soodabeh, Bodaghabadi Narges, Sadeghizadeh Majid, Adeli Mohsen

机构信息

Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

Department of Chemistry, Faculty of Science, Lorestan University, Khorram Abad, Iran.

出版信息

Lasers Med Sci. 2018 May;33(4):795-802. doi: 10.1007/s10103-017-2422-4. Epub 2017 Dec 21.

DOI:10.1007/s10103-017-2422-4
PMID:29264722
Abstract

In this work, we reported a facile method to produce stable aqueous graphene dispersion through direct exfoliation of graphite by modified hyperbranched polyglycerol. Size of graphene sheets was manipulated by simultaneous exfoliation and sonication of graphite, and functionalized graphene sheets with narrow size distribution were obtained. The polyglycerol-functionalized graphene sheets exhibited highly efficient cellular uptake and photothermal conversion, enabling it to serve as a photothermal agent for cancer therapy.

摘要

在这项工作中,我们报道了一种通过改性超支化聚甘油直接剥离石墨来制备稳定的石墨烯水分散体的简便方法。通过同时对石墨进行剥离和超声处理来控制石墨烯片的尺寸,从而获得了尺寸分布窄的功能化石墨烯片。聚甘油功能化的石墨烯片表现出高效的细胞摄取和光热转换能力,使其能够用作癌症治疗的光热剂。

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本文引用的文献

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Gold-coated magnetic nanoparticle as a nanotheranostic agent for magnetic resonance imaging and photothermal therapy of cancer.金包覆磁性纳米颗粒作为用于癌症磁共振成像和光热治疗的纳米诊疗剂。
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Strategies to Improve Cancer Photothermal Therapy Mediated by Nanomaterials.提高纳米材料介导的癌症光热治疗的策略。
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Graphene: a versatile nanoplatform for biomedical applications.石墨烯:用于生物医学应用的多功能纳米平台。
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Enhanced chemotherapy efficacy by sequential delivery of siRNA and anticancer drugs using PEI-grafted graphene oxide.使用聚乙二醇接枝的氧化石墨烯顺序递送小干扰RNA和抗癌药物增强化疗疗效
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