Gong Peiwei, Zhao Qiao, Dai Dujuan, Zhang Shumiao, Tian Zhenzhen, Sun Lu, Ren Jiashuo, Liu Zhe
Department of Chemistry and Chemical Engineering, Institute of Anticancer Agents Development and Theranostic Application, The Key Laboratory of Life-Organic Analysis, and Key Laboratory of Pharmaceutical Intermediate, and Analysis of Natural Medicine, Qufu Normal University, 57 Jingxuan West Road, Qufu, Shandong, P.R. China.
Chemistry. 2017 Dec 11;23(69):17531-17541. doi: 10.1002/chem.201702917. Epub 2017 Nov 14.
Fluorinated graphene (FG) possess distinctively novel properties different from graphene and is suitable for many biomedical applications. However, the hydrophobic nature and inert properties of FG limit its further application as a biological material. Here we show the preparation of nano-sized FG (ca. 60 nm) that exhibits high NIR absorbance for photothermal therapy. In order to make it stable in physiological solutions, the FG is enriched with oxygen and followed by covalent binding with chitosan as a novel pH-responsive nanocarrier. Furthermore, controlled loading of two anticancer drugs, doxorubicin (DOX) and camptothecin (CPT) has been realized and the functionalized ultrasmall FG shows remarkably high cytotoxicity toward Hela cancer cells compared to that loaded with either CPT or DOX only. This work established nano-sized FG as a novel photothermal agent due to its small size and can be used a stimulus-responsive nanocarrier for mixed drug delivery and combined therapy.
氟化石墨烯（FG）具有与石墨烯不同的独特新颖性质，适用于许多生物医学应用。然而，FG的疏水性和惰性限制了其作为生物材料的进一步应用。在此，我们展示了纳米尺寸FG（约60纳米）的制备，其对光热疗法表现出高近红外吸收率。为了使其在生理溶液中稳定，FG被富氧处理，随后与壳聚糖共价结合，形成一种新型的pH响应纳米载体。此外，已实现两种抗癌药物阿霉素（DOX）和喜树碱（CPT）的可控负载，与仅负载CPT或DOX的情况相比，功能化的超小FG对Hela癌细胞显示出显著高的细胞毒性。这项工作将纳米尺寸的FG确立为一种新型光热剂，因其尺寸小，可作为用于混合药物递送和联合治疗的刺激响应纳米载体。
