De Palo P, Maggiolino A, Ceci E, Calzaretti G, Centoducati P, Tateo A
Department of Veterinary Medicine, University "A. Moro" of Bari, Italy, Valenzano (Ba), Italy.
Equine Vet J. 2018 Jul;50(4):493-497. doi: 10.1111/evj.12799. Epub 2018 Jan 10.
Catecholamines are among the most frequently investigated parameters for studying sympathoadrenal activity in response to stress conditions.
To evaluate basal plasma concentrations of catecholamines (adrenaline, noradrenaline and dopamine) in healthy donkeys.
Cross-sectional study.
Catecholamine concentrations from 440 Martina Franca donkeys were determined: 269 females and 171 entire males, aged from 4 months to 24 years. Animals were subdivided into four age categories: under 12 months old (64 males and 54 females), from 13 to 36 months (56 males and 75 females), from 37 to 120 months (49 males and 80 females) and over 120 months (24 males and 38 females). Indwelling jugular catheters were inserted at least 12 h before drawing blood. The data set was subjected to analysis of variance considering age, sex and the two-way interaction between them as independent variables. Pearson's correlation coefficients between the three catecholamines were evaluated.
Confidence intervals (CI) for noradrenaline concentration ranged between 239.98 and 255.07 ng/L (mean 247.52 ng/L), for adrenaline between 129.27 and 137.90 ng/L (mean 133.59 ng/L), dopamine concentrations between 149.62 and 160.80 ng/L (mean 155.21 ng/L) and noradrenaline/adrenaline ratio between 1.91 and 2.05 (mean 1.98). Catecholamine plasma concentrations were not influenced by sex. Donkeys older than 37 months had lower adrenaline and noradrenaline plasma concentrations (P<0.001) and higher noradrenaline/adrenaline ratios (P<0.01) than younger animals.
Indwelling catheters and blood drawing procedures may have influenced catecholamine levels.
Catecholamine concentrations were established within a large group of healthy Martina Franca donkeys.
儿茶酚胺是研究应激条件下交感肾上腺活动时最常检测的参数之一。
评估健康驴的基础血浆儿茶酚胺（肾上腺素、去甲肾上腺素和多巴胺）浓度。
横断面研究。
测定了440头马尔蒂纳弗兰卡驴的儿茶酚胺浓度，其中雌性269头，雄性171头，年龄从4个月到24岁。动物被分为四个年龄组：12个月以下（雄性64头，雌性54头）、13至36个月（雄性56头，雌性75头）、37至120个月（雄性49头，雌性80头）和120个月以上（雄性24头，雌性38头）。在采血前至少12小时插入颈静脉留置导管。将数据集以年龄、性别及其二者的双向交互作用作为自变量进行方差分析。评估了三种儿茶酚胺之间的Pearson相关系数。
去甲肾上腺素浓度的置信区间（CI）在239.98至255.07 ng/L之间（均值247.52 ng/L），肾上腺素在129.27至137.90 ng/L之间（均值133.59 ng/L），多巴胺浓度在149.62至160.80 ng/L之间（均值155.21 ng/L），去甲肾上腺素/肾上腺素比值在1.91至2.05之间（均值1.98）。血浆儿茶酚胺浓度不受性别影响。37个月以上的驴血浆肾上腺素和去甲肾上腺素浓度低于年幼动物（P<0.001），而去甲肾上腺素/肾上腺素比值高于年幼动物（P<0.01）。
颈静脉留置导管和采血程序可能影响了儿茶酚胺水平。
在一大群健康的马尔蒂纳弗兰卡驴中确定了儿茶酚胺浓度。
