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热点直击:2017 年美国移植大会报道。

What's hot, what's new: Report from the American Transplant Congress 2017.

机构信息

Medstar Georgetown Transplant Institute, Georgetown University School of Medicine, Washington, DC, USA.

Immunobiology and Transplant Science Center, Houston Methodist Hospital, Texas Medical Center, Houston, TX, USA.

出版信息

Am J Transplant. 2018 Feb;18(2):308-320. doi: 10.1111/ajt.14628. Epub 2018 Jan 21.

Abstract

Significant advances in clinical practice as well as basic and translational science were presented at the American Transplant Congress this year. Topics included innovative clinical trials to recent advances in our basic understanding of the scientific underpinnings of transplant immunology. Key areas of interest included the following: clinical trials utilizing hepatitis C virus-positive (HCV ) donors for HCV recipients, the impact of the new allocation policies, normothermic perfusion, novel treatments for desensitization, attempts at precision medicine, advances in xenotransplantation, the role of mitochondria and exosomes in rejection, nanomedicine, and the impact of the microbiota on transplant outcomes. This review highlights some of the most interesting and noteworthy presentations from the meeting.

摘要

今年的美国移植大会展示了临床实践以及基础和转化科学方面的重大进展。议题包括创新的临床试验以及我们对移植免疫学科学基础的最新认识的进展。主要关注领域包括以下方面:利用丙型肝炎病毒(HCV)阳性供体进行 HCV 受者的临床试验、新分配政策的影响、常温灌流、脱敏的新疗法、精准医学的尝试、异种移植的进展、线粒体和外泌体在排斥反应中的作用、纳米医学以及微生物组对移植结果的影响。本文综述了会议中最有趣和最值得注意的一些演讲。

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