Patel S D, Gupta B, Yalkowsky S H
J Parenter Sci Technol. 1989 Jan-Feb;43(1):8-14.
The medium offering the greatest resistance to heat transfer from the freeze-dryer shelf to the moving and subliming interface within the product is the space between the flat shelf top and the concave vial bottom. The resistance to heat transfer can be greatly reduced by improving the thermal conductivity of this intervening space. Several heat transfer augmentation devices, which fill this gap, are described. The devices are inexpensive and easy to use. Experimental data show that the resistance of the intervening space is reduced appreciably and the drying time is greatly reduced.
对热量从冻干机搁板传递至产品内部移动且升华界面形成最大阻力的介质，是平板搁板顶部与凹形瓶底部之间的空间。通过提高这一中间空间的热导率，可大幅降低热传递阻力。本文描述了几种填充此间隙的强化传热装置。这些装置价格低廉且易于使用。实验数据表明，中间空间的阻力显著降低，干燥时间大幅缩短。
