School of Chemistry, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.
Photochem Photobiol Sci. 2018 Mar 14;17(3):281-289. doi: 10.1039/c7pp00225d.
Gold nanoparticles (AuNPs; ca. 4 nm) were synthesised and functionalised with a mixed monolayer of polyethylene glycol (PEG) and one of two zinc phthalocyanines (ZnPcs), the difference between the two molecules was the length of the carbon chain that connects the Pc to the gold core. The chain was composed of either three (C3Pc) or eleven (C11Pc) carbon atoms. The C11Pc photosensitiser displayed higher fluorescence emission intensity than the C3Pc in solution. By contrast, the C3Pc photosensitiser exhibited higher fluorescence when bound to the surface of the AuNPs than the C11Pc, despite the shorter carbon chain which was expected to quench the fluorescence. In addition, the C3Pc nanoparticle conjugates exhibited an enhancement in the production of singlet oxygen (O). The metal-enhanced O production led to a remarkable photodynamic efficacy for the treatment of human breast cancer cells.
金纳米粒子（AuNPs；约 4nm）通过聚乙二醇（PEG）和两种锌酞菁（ZnPcs）之一的混合单层进行合成和功能化，这两种分子的区别在于连接卟啉环和金核的碳链的长度。该链由三个（C3Pc）或十一个（C11Pc）碳原子组成。C11Pc 光敏剂在溶液中的荧光发射强度高于 C3Pc。相比之下，C3Pc 光敏剂在结合到 AuNPs 表面时表现出比 C11Pc 更高的荧光，尽管较短的碳链预计会猝灭荧光。此外，C3Pc 纳米粒子缀合物在单线态氧（O）的产生方面表现出增强。金属增强的 O 产生导致对人类乳腺癌细胞的治疗具有显著的光动力疗效。
