Department of Chemistry, University of Delhi, Delhi 110007, India.
J Nanosci Nanotechnol. 2019 Nov 1;19(11):6942-6948. doi: 10.1166/jnn.2019.16719.
Herein, we investigate the effect of the surface attachment of gold nanoparticles (AuNPs) on photosensitiser-entrapped organically modified silica (ormosil) nanoparticles for enhanced photodynamic therapy (PDT). Photosensitiser methylene blue (MB)-entrapped ormosil nanoparticles of three different diameters (30/55/80 nm) were synthesised, and AuNPs were attached to their surface. Subsequent light irradiation with a 630 nm laser resulted in the production of singlet oxygen (O₂), with different amounts depending on the diameter of the ormosil nanoparticle. Enhancement in O₂ production was observed upon the AuNP attachment on the ormosil surface. studies in pancreatic cancer (Panc-1) cells have demonstrated that cellular uptake and photodynamic cytotoxicity are also dependent on the size of ormosil nanoparticles and AuNP attachment. These studies pave the way for designing ormosil nanoparticles with suitable size and surface attachment for PDT applications.
在这里，我们研究了金纳米粒子（AuNPs）表面附着对光敏剂包埋的有机改性硅（ormosil）纳米颗粒的影响，以增强光动力疗法（PDT）。合成了三种不同直径（30/55/80nm）的甲烯蓝（MB）包埋的 ormosil 纳米颗粒，并将 AuNPs 附着在其表面。随后用 630nm 激光进行光照，产生单重态氧（O₂），其产量取决于 ormosil 纳米颗粒的直径。在 ormosil 表面附着 AuNP 时，观察到 O₂ 产量的增加。在胰腺癌细胞（Panc-1）中的研究表明，细胞摄取和光动力细胞毒性也取决于 ormosil 纳米颗粒的大小和 AuNP 的附着。这些研究为设计具有合适尺寸和表面附着的 ormosil 纳米颗粒用于 PDT 应用铺平了道路。
