用于表皮生长因子受体过表达癌症的选择性光动力疗法的肽导向酞菁-金纳米颗粒
Peptide directed phthalocyanine-gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers.
作者信息
Goddard Zoë Rachael, Beekman Andrew Michael, Cominetti Marco M D, O'Connell Maria A, Chambrier Isabelle, Cook Michael J, Marín María J, Russell David A, Searcey Mark
机构信息
School of Pharmacy, University of East Anglia Norwich Research Park Norwich NR4 7TJ UK
School of Chemistry, University of East Anglia Norwich Research Park Norwich NR4 7TJ UK.
出版信息
RSC Med Chem. 2020 Nov 19;12(2):288-292. doi: 10.1039/d0md00284d.
Gold nanoparticles, covalently functionalised with the photosensitiser C11Pc and PEG, were actively targeted towards epidermal growth factor receptor overexpressing cancers using the peptide FITC-βAAEYLRK. Selective phototoxicity was observed at nanomolar concentrations with minimal dark toxicity.
用光敏剂C11Pc和聚乙二醇（PEG）进行共价功能化修饰的金纳米颗粒，使用肽FITC-βAAEYLRK将其主动靶向于表皮生长因子受体过表达的癌症。在纳摩尔浓度下观察到了选择性光毒性，且暗毒性极小。
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