Sun Haiyan, Gong Lei, Zhao Gang, Zhan Hongdian, Meng Bin, Yu Zhentao, Pan Zhanyu
Department of Integrative Oncology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy of Tianjin City, Tianjin, China.
Department of Esophageal Cancer, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy of Tianjin City, Tianjin, China.
J Surg Oncol. 2018 Mar;117(4):588-596. doi: 10.1002/jso.24905. Epub 2017 Dec 19.
Primary malignant melanoma of esophagus (PMME) is a remarkably rare and highly aggressive tumor. Studies related with clinicopathological findings, staging classification, and clinical outcomes are lacking.
We reviewed 21 cases of PMME at the Tianjin Medical University Cancer Institute and Hospital from January 2002 to February 2017.
Nineteen patients (90.48%) presented a history of dysphagia for months, and two (9.52%) experienced retrosternal pain. Histologically, tumors were composed of atypical melanocytes with melanocytosis surrounding the tumor. The overall survival was 1-40 months, with the median time of 10 months. The mucosal staging classification for upper aerodigestive tract showed better distribution of overall survival with different stages than that of the American Joint Commission on Cancer staging classification for esophagus, but without statistical difference. Both the clinical and pathological characteristics were not highly consistent with overall survival.
PMME is a considerably aggressive tumor with poor prognosis. The staging classification of mucosal melanoma of the upper aerodigestive tract may be a good option for PMME patients.
原发性食管恶性黑色素瘤（PMME）是一种极为罕见且侵袭性很强的肿瘤。目前缺乏与临床病理特征、分期分类及临床结局相关的研究。
我们回顾了2002年1月至2017年2月在天津医科大学肿瘤医院的21例PMME病例。
19例患者（90.48%）有长达数月的吞咽困难病史，2例（9.52%）出现胸骨后疼痛。组织学上，肿瘤由非典型黑素细胞组成，肿瘤周围有黑素增多。总生存期为1至40个月，中位时间为10个月。上消化道黏膜分期分类显示不同分期的总生存期分布比美国癌症联合委员会食管分期分类更好，但无统计学差异。临床和病理特征与总生存期均无高度一致性。
PMME是一种侵袭性很强且预后较差的肿瘤。上消化道黏膜黑色素瘤的分期分类可能是PMME患者的一个较好选择。
