Wang Qian-Qian, Li Yan-Mei, Qin Geng, Liu Fang, Xu Ying-Ying
Department of Gastroenterology, Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, China.
Department of Gastroenterology, China-Japan Friendship Hospital, Beijing 100029, China.
World J Clin Cases. 2023 Feb 26;11(6):1426-1433. doi: 10.12998/wjcc.v11.i6.1426.
Primary malignant melanoma of the esophagus (PMME) is a rare malignant disease whose clinical and molecular pathological features, origin and pathogenesis, diagnosis and treatment have not been elucidated.
In this paper, we report a case of a 73-year-old male with PMME. The patient complained of progressive dysphagia accompanied by substantial weight loss. Gastroscopy revealed a purple black bulging-type mass in the lower esophagus with easy bleeding on contact and scattered satellite lesions in the stomach. Histopathological biopsy revealed melanocytes in the esophageal mucosa. Physical examination and multidisciplinary consultation led to diagnostic exclusion of melanoma originating in other organs, such as the skin. Through this case report and literature review, we aimed to describe the clinical and molecular pathological features of PMME and summarize possible pathways of pathogenesis as well as cutting-edge therapeutic advances.
PMME is a rare malignancy of the esophagus with a poor prognosis. Clinicians should raise their awareness and be able to identify early lesions.
原发性食管恶性黑色素瘤（PMME）是一种罕见的恶性疾病，其临床和分子病理特征、起源和发病机制、诊断和治疗尚未阐明。
本文报告1例73岁男性PMME患者。患者主诉进行性吞咽困难并伴有显著体重减轻。胃镜检查发现食管下段有一紫黑色隆起型肿物，触之易出血，胃内有散在卫星灶。组织病理学活检显示食管黏膜中有黑色素细胞。体格检查及多学科会诊排除了起源于其他器官（如皮肤）的黑色素瘤。通过本病例报告及文献复习，旨在描述PMME的临床和分子病理特征，总结可能的发病途径以及前沿治疗进展。
PMME是一种罕见的食管恶性肿瘤，预后较差。临床医生应提高认识，能够早期识别病变。
