Fundamental Research Laboratories, KOSÉ Corporation, Tokyo, Japan.
Department of Dermatology, Japanese Red Cross Kanazawa Hospital, Ishikawa, Japan.
J Dermatol. 2018 Feb;45(2):145-149. doi: 10.1111/1346-8138.14175. Epub 2017 Dec 20.
Erythropoietic protoporphyria is a genetic disease characterized by sensitivity to sunlight caused by the accumulation of protoporphyrin IX. Photoprotection against ultraviolet A and visible light is necessary for erythropoietic porphyria patients because the absorption spectrum of protoporphyrin IX lies in both ultraviolet A and visible light region. We developed a novel index, in vitro porphyrin protection factor, based on the protoporphyrin IX absorbance spectrum. We also selected appropriate photoprotective products designed according to protoporphyrin IX absorbance. The porphyrin protection factors of a combination of make-up base with a powder as well as with a liquid foundation were significantly higher than those of a conventional sunscreen product, even at a small application dose. An in-use test carried out for 6 months showed that the efficacy of these products was 78.3%, and no adverse reactions were observed. Male subjects preferred liquid foundation, whereas all female subjects used powder foundation. The preference of the subjects could lead to the long-term use of the tested products. In conclusion, this study provided a new approach to improve photoprotection in erythropoietic protoporphyria patients.
红细胞生成性原卟啉症是一种遗传性疾病，其特征是由于原卟啉 IX 的积累而对阳光敏感。由于原卟啉 IX 的吸收光谱位于紫外线 A 和可见光区域，因此红细胞生成性卟啉症患者需要进行紫外线 A 和可见光的光保护。我们根据原卟啉 IX 的吸收光谱开发了一种新的指标，即体外卟啉保护因子。我们还根据原卟啉 IX 的吸收选择了合适的光保护产品进行设计。与传统防晒霜相比，即使在小剂量使用的情况下，组合使用粉底和粉饼或粉底的组合的卟啉保护因子显著更高。进行了为期 6 个月的使用测试表明，这些产品的功效为 78.3%，且未观察到不良反应。男性受试者更喜欢液体粉底，而所有女性受试者都使用粉饼。受试者的偏好可能会导致对测试产品的长期使用。总之，本研究为改善红细胞生成性原卟啉症患者的光保护提供了一种新方法。
