Xu Kun, Gu Donghua, Zhang Yong, Su Qian, Chen Jiangang, Gu Zhibo
Department of Urology, Nantong First People's Hospital, Affiliated Hospital 2 of Nantong University, No. 666 Victory Road, Chongchuan District, Nantong, Jiangsu 226200, China.
Department of Anesthesiology, Affiliated Hospital 2 of Nantong University, Nantong, Jiangsu 226200, China.
ACS Biomater Sci Eng. 2025 Sep 8;11(9):5228-5236. doi: 10.1021/acsbiomaterials.5c00960. Epub 2025 Aug 24.
Bladder cancer is one of the most prevalent malignancies of the urinary system and poses significant therapeutic challenges, including high recurrence rates, drug resistance, and treatment-related side effects. In recent years, Schottky junction nanocatalysts have attracted considerable attention in the field of oncology due to their enhanced light-driven electrodynamic properties and promising therapeutic potential. This review provided a comprehensive overview of the underlying mechanisms of Schottky junction nanocatalysts and their core advantages. Moreover, the application of nanomaterials in multimodal therapy for bladder cancer was further elaborated, including photothermal therapy (PTT), photodynamic therapy (PDT), and synergistic chemodynamic therapy. By analyzing the latest advances in preclinical research, we highlighted the role of these nanocatalysts in enhancing therapeutic efficacy, minimizing systemic toxicity, and improving patient survival outcomes. Simultaneously, it outlines the present issues with nanomaterials and the clinical barriers impeding their widespread adoption. These findings offer valuable insights into the future clinical translation of nanotechnology-based treatments for bladder cancer.
膀胱癌是泌尿系统最常见的恶性肿瘤之一，带来了重大的治疗挑战，包括高复发率、耐药性和治疗相关的副作用。近年来，肖特基结纳米催化剂因其增强的光驱动电动力学特性和有前景的治疗潜力，在肿瘤学领域引起了相当大的关注。本综述全面概述了肖特基结纳米催化剂的潜在机制及其核心优势。此外，还进一步阐述了纳米材料在膀胱癌多模态治疗中的应用，包括光热疗法（PTT）、光动力疗法（PDT）和协同化学动力学疗法。通过分析临床前研究的最新进展，我们强调了这些纳米催化剂在提高治疗效果、最小化全身毒性和改善患者生存结果方面的作用。同时，概述了纳米材料目前存在的问题以及阻碍其广泛应用的临床障碍。这些发现为基于纳米技术的膀胱癌治疗的未来临床转化提供了有价值的见解。
