Wang Zhen-Yu, Wan Jia-Hao, Wang Gao-Yin, Jin Ruo-Xing, Lan Quan, Wang Xi-Sheng
Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, 230026, P.R. China.
Chem Asian J. 2018 Feb 2;13(3):261-265. doi: 10.1002/asia.201701655. Epub 2018 Jan 17.
An efficient nickel-catalyzed Heck-type reaction between styrenes and fluoroalkyl iodine has been developed. This novel transformation has demonstrated a broad substrate scope, mild reaction conditions and excellent E-stereoselectivity. This efficient synthetic method has been applied to the late-stage monofluoroacetation of biologically active molecules. Mechanistic investigations indicate that a monofluoroalkyl radical is involved in the catalytic cycle.
