Tang Wei-Ke, Xu Zhuo-Wei, Xu Jun, Tang Fei, Li Xiao-Xuan, Dai Jian-Jun, Xu Hua-Jian, Feng Yi-Si
Anhui Province Key Laboratory of Advance Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering , Hefei University of Technology , Hefei 230009 , P. R. China.
School of Food and Biological Engineering , Hefei University of Technology , Hefei 230009 , P. R. China.
Org Lett. 2019 Jan 4;21(1):196-200. doi: 10.1021/acs.orglett.8b03656. Epub 2018 Dec 14.
A cobaloxime-catalyzed photochemical synthesis of allyl monofluorides from styrenes is described herein. This method is characterized by mild reaction conditions, low-cost catalyst, and broad substrate scope. Furthermore, this convenient method will provide a facile synthesis toward novel monofluoroalkylated natural product and pharmaceutical derivatives. Mechanistic investigations indicate that a monofluoroalkyl radical is involved in the catalytic cycle.
本文描述了一种由钴肟催化的苯乙烯光化学合成烯丙基单氟化物的方法。该方法具有反应条件温和、催化剂成本低、底物范围广的特点。此外，这种简便的方法将为新型单氟烷基化天然产物和药物衍生物的合成提供便利。机理研究表明，催化循环中涉及单氟烷基自由基。
