Jafari Mohieddin, Ansari-Pour Naser, Azimzadeh Sadegh, Mirzaie Mehdi
Drug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.
Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran.
PLoS One. 2017 Dec 21;12(12):e0189922. doi: 10.1371/journal.pone.0189922. eCollection 2017.
It is nearly half a century past the age of the introduction of the Central Dogma (CD) of molecular biology. This biological axiom has been developed and currently appears to be all the more complex. In this study, we modified CD by adding further species to the CD information flow and mathematically expressed CD within a dynamic framework by using Boolean network based on its present-day and 1965 editions. We show that the enhancement of the Dogma not only now entails a higher level of complexity, but it also shows a higher level of robustness, thus far more consistent with the nature of biological systems. Using this mathematical modeling approach, we put forward a logic-based expression of our conceptual view of molecular biology. Finally, we show that such biological concepts can be converted into dynamic mathematical models using a logic-based approach and thus may be useful as a framework for improving static conceptual models in biology.
分子生物学的中心法则（CD）提出至今已近半个世纪。这条生物学公理不断发展，如今显得愈发复杂。在本研究中，我们对中心法则进行了修改，在信息流中增加了更多物种，并基于其当前版本和1965年版本，通过布尔网络在动态框架内对中心法则进行了数学表达。我们表明，对法则的扩展不仅带来了更高层次的复杂性，还展现出更高的稳健性，因此更符合生物系统的本质。通过这种数学建模方法，我们提出了基于逻辑的分子生物学概念视图表达。最后，我们表明，此类生物学概念可以通过基于逻辑的方法转化为动态数学模型，从而可能作为改进生物学静态概念模型的框架发挥作用。
