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一名10岁儿童的大疱性系统性红斑狼疮。

Bullous systemic lupus erythematosus in a 10-year-old child.

作者信息

Hans-Bittner Nelise Ritter, Bittner Guilherme Canho, Hans Günter, Takita Luiz Carlos

机构信息

Dr. Günter Hans Department of Dermatology at Hospital Universitário Maria Aparecida Pedrossian, of the Universidade Federal de Mato Grosso do Sul (HUMAP-UFMS) - Campo Grande (MS), Brazil.

Discipline of Dermatology of the Faculdade de Medicina, Universidade Federal de Mato Grosso do Sul (FAMED-UFMS) - Campo Grande (MS), Brazil.

出版信息

An Bras Dermatol. 2017;92(5 Suppl 1):37-39. doi: 10.1590/abd1806-4841.20176074.

DOI:10.1590/abd1806-4841.20176074
PMID:29267441
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5726672/
Abstract

Bullous systemic lupus erythematosus (BSLE) is a rare autoimmune subepidermal blistering disease, with few cases described in childhood. It has different clinical-pathological features. We report a case of BSLE in a 10-year-old child with systemic lupus erythematosus, treated with prednisone and hydroxychloroquine. There was complete remission with dapsone, with no recurrence of skin lesions throughout one year of follow-up. We highlight the rarity and early age of occurrence.

摘要

大疱性系统性红斑狼疮（BSLE）是一种罕见的自身免疫性表皮下大疱性疾病，儿童病例报道较少。它具有不同的临床病理特征。我们报告一例10岁患有系统性红斑狼疮的儿童BSLE病例，采用泼尼松和羟氯喹治疗。使用氨苯砜后完全缓解，在一年的随访中皮肤病变未复发。我们强调了其罕见性和发病年龄早的特点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fee8/5726672/daae206bdb13/abd-92-05-s1-0037-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fee8/5726672/e5bc9e494c78/abd-92-05-s1-0037-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fee8/5726672/60476ac37090/abd-92-05-s1-0037-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fee8/5726672/f66e7acdf4c6/abd-92-05-s1-0037-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fee8/5726672/0f8f3d138944/abd-92-05-s1-0037-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fee8/5726672/f18de9a28ee8/abd-92-05-s1-0037-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fee8/5726672/daae206bdb13/abd-92-05-s1-0037-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fee8/5726672/e5bc9e494c78/abd-92-05-s1-0037-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fee8/5726672/60476ac37090/abd-92-05-s1-0037-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fee8/5726672/f66e7acdf4c6/abd-92-05-s1-0037-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fee8/5726672/0f8f3d138944/abd-92-05-s1-0037-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fee8/5726672/f18de9a28ee8/abd-92-05-s1-0037-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fee8/5726672/daae206bdb13/abd-92-05-s1-0037-g02.jpg

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本文引用的文献

1
Bullous systemic lupus erythematosus: a review and update to diagnosis and treatment.大疱性系统性红斑狼疮：诊断与治疗的综述及更新
Am J Clin Dermatol. 2014 Dec;15(6):517-24. doi: 10.1007/s40257-014-0098-0.
2
Childhood-onset bullous systemic lupus erythematosus.儿童期起病的大疱性系统性红斑狼疮。
Lupus. 2014 Nov;23(13):1422-5. doi: 10.1177/0961203314544187. Epub 2014 Jul 29.
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Bullous systemic lupus erythematosus.大疱性系统性红斑狼疮
Indian J Dermatol. 2013 Nov;58(6):492. doi: 10.4103/0019-5154.119973.
4
Bullous systemic lupus erythematosus: differential diagnosis with dermatitis herpetiformis.大疱性系统性红斑狼疮：与疱疹样皮炎的鉴别诊断
An Bras Dermatol. 2011 Jul-Aug;86(4 Suppl 1):S92-5. doi: 10.1590/s0365-05962011000700024.
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Bullous lupus: an unusual initial presentation of systemic lupus erythematosus in an adolescent girl.大疱性狼疮：一名青春期女孩系统性红斑狼疮的不寻常首发表现。
Pediatr Dermatol. 2010 Jul-Aug;27(4):373-6. doi: 10.1111/j.1525-1470.2010.01179.x.
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Bullous SLE: a phenotypically distinctive but immunologically heterogeneous bullous disorder.大疱性系统性红斑狼疮：一种表型独特但免疫异质性的大疱性疾病。
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