Universidade Federal de Minas Gerais - UFMG, School of Dentistry, Department of Oral Surgery and Pathology, Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais - UFMG, Institute of Biological Sciences, Department of Microbiology. Belo Horizonte, MG, Brazil.
Braz Oral Res. 2017 Dec 18;31:e103. doi: 10.1590/1807-3107bor-2017.vol31.0103.
The process involved in periapical lesions, which occur as an outcome of pulpal necrosis, is regulated by the immune system including regulatory T cells (Treg) and T helper 17 cell (Th17) responses. The objective of this study was to conduct a frequency systematic review to determine the presence of Treg/Th17 responses and the influence of these cells in the progression of chronic inflammatory periapical lesions in humans. A systematic computerized search was carried out in Pubmed, Medline, Web of Science and Scopus electronic databases from their date of inception through the first week of May 2017. In addition, the reference lists of the included articles and the grey literature were hand-searched. Articles that evaluated the presence and influence of Treg/Th17 in the progression of human periapical lesions were included. Study selection and the quality assessment of the included articles (using the Newcastle-Ottawa scale) were carried out by two authors. Fifty-seven titles/abstracts were screened and eight studies met the eligibility criteria and were included in this systematic review. The included studies showed large variation in the type of periapical lesion assessed, mean age, age range, type of experiment and findings regarding the participation of Th17 and Treg in the status of inflammatory periapical lesions. The studies showed the involvement of Treg in the modulation of the inflammatory response in radicular cysts and periapical granulomas. This systematic review highlights the relationship between Treg and Th17 acting in a subtle balance inhibiting or promoting the progression of human periapical lesions.
根尖周病变的发生是牙髓坏死的结果，其过程受免疫系统的调节，包括调节性 T 细胞（Treg）和辅助性 T 细胞 17（Th17）应答。本研究的目的是进行频率系统评价，以确定 Treg/Th17 应答的存在以及这些细胞在人类慢性炎症性根尖周病变进展中的影响。通过计算机在 Pubmed、Medline、Web of Science 和 Scopus 电子数据库中从建库开始至 2017 年 5 月第一周进行了系统检索。此外，还对纳入文章的参考文献列表和灰色文献进行了手工检索。纳入了评估 Treg/Th17 在人类根尖周病变进展中的存在和影响的文章。两名作者对纳入文章进行了研究选择和质量评估（使用纽卡斯尔-渥太华量表）。筛选了 57 个标题/摘要，有 8 项研究符合纳入标准，并纳入本系统评价。纳入的研究在评估的根尖周病变类型、平均年龄、年龄范围、实验类型以及关于 Th17 和 Treg 参与炎症性根尖周病变的发现方面存在很大差异。这些研究表明 Treg 参与了根囊肿和根尖肉芽肿中炎症反应的调节。本系统评价强调了 Treg 和 Th17 之间的关系，它们在抑制或促进人类根尖周病变进展方面起着微妙的平衡作用。
