中年心血管健康与 20 年认知衰退：动脉粥样硬化风险社区研究结果。
Midlife cardiovascular health and 20-year cognitive decline: Atherosclerosis Risk in Communities Study results.
机构信息
Department of Neurosciences and Shiley-Marcos Alzheimer's Disease Research Center, University of California San Diego, San Diego, CA, USA.
Institute of Gerontology, Department of Healthcare Sciences, Wayne State University, Detroit, MI, USA.
出版信息
Alzheimers Dement. 2018 May;14(5):579-589. doi: 10.1016/j.jalz.2017.11.002. Epub 2017 Dec 18.
Abstract
INTRODUCTION
The aim was to examine associations between midlife cardiovascular health (CVH) and 20-year cognitive decline among blacks and whites.
METHODS
Midlife CVH metrics (American Heart Association's Life's Simple 7) were calculated and examined in relation to midlife and 20-year change in cognitive function among 13,270 whites and blacks from the Atherosclerosis Risk in Communities Cohort Study. We used linear mixed models to estimate adjusted associations of midlife CVH with midlife cognitive status and change.
RESULTS
Higher midlife (Life's Simple 7) scores and individual metrics, particularly blood pressure and glucose, were associated with better midlife cognition and reduced 20-year decline. Midlife CVH 20-year neuroprotection was more pronounced among whites than blacks.
DISCUSSION
Better midlife CVH was associated with higher midlife and reduced decline in cognitive function 20 years later. However, the benefits of midlife CVH on cognition were stronger for whites than for blacks. Our findings suggest that improved midlife CVH may promote enduring cognitive health.
摘要
简介
本研究旨在探讨黑人和白人中年心血管健康（CVH）与 20 年认知能力下降之间的关系。
方法
在动脉粥样硬化风险社区研究（Atherosclerosis Risk in Communities Cohort Study）中，我们对 13270 名白人和黑人进行了中年 CVH 指标（美国心脏协会的“生命简单 7”）的计算，并与认知功能的中年和 20 年变化进行了检查。我们使用线性混合模型来估计中年 CVH 与中年认知状态和变化的调整关联。
结果
较高的中年（“生命简单 7”）评分和个体指标，特别是血压和血糖，与更好的中年认知能力和 20 年认知能力下降减少相关。中年 CVH 对神经的 20 年保护作用在白人中比在黑人中更为明显。
讨论
更好的中年 CVH 与更高的中年认知能力和 20 年后认知功能下降减少有关。然而，中年 CVH 对认知的益处对于白人来说比黑人更强。我们的研究结果表明，改善中年 CVH 可能促进持久的认知健康。
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