a National Organization for Drug Control & Research , Cairo , Egypt.
b Department of Pharmacognosy, College of Pharmacy , Umm Al-Qura University , Makkah , Saudi Arabia.
Arch Physiol Biochem. 2018 Dec;124(5):383-389. doi: 10.1080/13813455.2017.1419493. Epub 2017 Dec 21.
Diabetes is a group of metabolic diseases characterised by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is associated with long-term damage and dysfunction of many organs. Diabetes caused 1.5 million deaths in 2012, with hyperglycemia causing an additional 2.2 million deaths, as it is associated with increased risk of cardiovascular and other diseases. Various types of plants have been used for several centuries worldwide not only as dietary supplements but also as traditional treatment regimens for many diseases. So far, a large number of traditionally claimed plant medicine has been tested for diabetes and some of them showed a promising therapeutic potential. The main focus of this review is to describe what we know to date of herbal extracts, along with their glucose-lowering mechanisms, which are either through insulin-mimicking activity, enhanced β-cells regeneration, or glucose uptake.
糖尿病是一组以高血糖为特征的代谢性疾病，由胰岛素分泌缺陷或胰岛素作用缺陷或两者共同引起。糖尿病的慢性高血糖与许多器官的长期损伤和功能障碍有关。2012 年，糖尿病导致 150 万人死亡，其中 220 万人的死亡与高血糖有关，因为它与心血管和其他疾病的风险增加有关。几个世纪以来，世界各地的各种植物不仅被用作膳食补充剂，也被用作许多疾病的传统治疗方案。到目前为止，已经有大量传统上声称的植物药被用于治疗糖尿病，其中一些显示出有希望的治疗潜力。这篇综述的主要重点是描述我们目前所知道的草药提取物，以及它们降低血糖的机制，这些机制要么通过模拟胰岛素的活性，要么通过增强β细胞的再生，或者通过葡萄糖摄取。
