H3N2 流感疫苗：近期挑战。
Influenza H3N2 Vaccines: Recent Challenges.
机构信息
Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392 Giessen, Germany; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Egypt.
Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392 Giessen, Germany.
出版信息
Trends Microbiol. 2018 Feb;26(2):87-89. doi: 10.1016/j.tim.2017.12.003.
H3N2-subtype influenza A viruses are major causes of seasonal influenza epidemics. Emerging H3N2 variants require the annual adjustment of the vaccine strain. Recently, studies addressing the reduced effectiveness of current H3N2 vaccines have identified production-related substitutions in the viral hemagglutinin antigen as a possible cause for reduced vaccine efficacy.
H3N2 亚型甲型流感病毒是季节性流感流行的主要原因。新出现的 H3N2 变异株需要每年调整疫苗株。最近，针对当前 H3N2 疫苗效力降低的研究发现，病毒血凝素抗原的生产相关突变可能是疫苗效力降低的一个原因。
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