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2019-2020 北半球流感疫苗中 H3N2 组份的抗原性评估。

Antigenic assessment of the H3N2 component of the 2019-2020 Northern Hemisphere influenza vaccine.

机构信息

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

出版信息

Nat Commun. 2020 May 15;11(1):2445. doi: 10.1038/s41467-020-16183-y.

DOI:10.1038/s41467-020-16183-y
PMID:32415074
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7229105/
Abstract

The 2019-2020 Northern Hemisphere influenza vaccine includes antigens from 3c3.A H3N2 viruses; however, over half of circulating H3N2 viruses belong to subclade 3c2.A1b. Here, we analyze antibody responses elicited by the egg-adapted 3c3.A H3N2 vaccine strain in ferrets and humans. We find that this vaccine strain elicits antibodies that have reduced reactivity to a wild-type 3c3.A strain and very limited reactivity to 3c2.A strains, including the currently circulating 3c2.A1b strain.

摘要

2019-2020 年北半球流感疫苗包含 3c3.A H3N2 病毒的抗原；然而，超过一半的循环 H3N2 病毒属于 3c2.A1b 亚系。在这里，我们分析了适应鸡蛋的 3c3.A H3N2 疫苗株在雪貂和人类中引起的抗体反应。我们发现，这种疫苗株引起的抗体对野生型 3c3.A 株的反应性降低，对包括当前流行的 3c2.A1b 株在内的 3c2.A 株的反应性非常有限。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15b5/7229105/fcc742ebc979/41467_2020_16183_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15b5/7229105/4545aa356562/41467_2020_16183_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15b5/7229105/fcc742ebc979/41467_2020_16183_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15b5/7229105/4545aa356562/41467_2020_16183_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15b5/7229105/fcc742ebc979/41467_2020_16183_Fig2_HTML.jpg

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