Wang Jingwen, Song Xiumei, Wang Mengfei
Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, 200438, PR China.
Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, 200438, PR China.
Dev Comp Immunol. 2018 Jun;83:89-95. doi: 10.1016/j.dci.2017.12.017. Epub 2017 Dec 19.
Hematophagous arthropods are medically important disease vectors that transmit a variety of pathogens. Unlike mammals that employ both innate and adaptive immunity to clear invading pathogens, these vectors rely mainly on an innate immune system to combat pathogens. Peptidoglycan recognition proteins (PGRPs) are important components of innate immune signaling pathways and are responsible for recognizing microbe-associated molecular patterns (MAMPs), thus regulating host immune interactions with both harmful and helpful microbes. Here we review a number of recent studies in different vectors that address the function of PGRPs in immune regulation. Further, we discuss the variation of PGRPs between vectors and Drosophila.
吸血节肢动物是具有重要医学意义的疾病传播媒介，可传播多种病原体。与利用先天免疫和适应性免疫来清除入侵病原体的哺乳动物不同，这些媒介主要依靠先天免疫系统来对抗病原体。肽聚糖识别蛋白（PGRPs）是先天免疫信号通路的重要组成部分，负责识别微生物相关分子模式（MAMPs），从而调节宿主与有害和有益微生物的免疫相互作用。在此，我们综述了近期在不同媒介中开展的一些研究，这些研究探讨了PGRPs在免疫调节中的功能。此外，我们还讨论了媒介与果蝇之间PGRPs的差异。
