果蝇免疫反应中的模式识别受体。

Pattern recognition receptors in Drosophila immune responses.

机构信息

Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, China; Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, China.

出版信息

Dev Comp Immunol. 2020 Jan;102:103468. doi: 10.1016/j.dci.2019.103468. Epub 2019 Aug 17.

DOI:10.1016/j.dci.2019.103468

PMID:31430488

Abstract

Insects, which lack the adaptive immune system, have developed sophisticated innate immune system consisting of humoral and cellular immune responses to defend against invading microorganisms. Non-self recognition of microbes is the front line of the innate immune system. Repertoires of pattern recognition receptors (PRRs) recognize the conserved pathogen-associated molecular patterns (PAMPs) present in microbes, such as lipopolysaccharide (LPS), peptidoglycan (PGN), lipoteichoic acid (LTA) and β-1, 3-glucans, and induce innate immune responses. In this review, we summarize current knowledge of the structure, classification and roles of PRRs in innate immunity of the model organism Drosophila melanogaster, focusing mainly on the peptidoglycan recognition proteins (PGRPs), Gram-negative bacteria-binding proteins (GNBPs), scavenger receptors (SRs), thioester-containing proteins (TEPs), and lectins.

摘要

昆虫缺乏适应性免疫系统，它们已经进化出复杂的先天免疫系统，包括体液和细胞免疫反应，以抵御入侵的微生物。微生物的非自我识别是先天免疫系统的第一道防线。模式识别受体 (PRR) 的组合识别存在于微生物中的保守病原体相关分子模式 (PAMP)，例如脂多糖 (LPS)、肽聚糖 (PGN)、脂磷壁酸 (LTA) 和 β-1,3-葡聚糖，并诱导先天免疫反应。在这篇综述中，我们总结了模式生物黑腹果蝇先天免疫中 PRR 的结构、分类和作用的最新知识，主要集中在肽聚糖识别蛋白 (PGRPs)、革兰氏阴性菌结合蛋白 (GNBPs)、清道夫受体 (SRs)、硫酯蛋白 (TEPs) 和凝集素上。