Department of Systems Medicine, Medical School, University of Rome "Tor Vergata", Rome, Italy.
Eur Rev Med Pharmacol Sci. 2017 Dec;21(24):5827-5836. doi: 10.26355/eurrev_201712_14031.
To evaluate the impact of a new formulation of probiotic mouthwash (PM), using Biocult strong® dissolved in neutral mouthwash.
Forty-two patients with cardiovascular disease (CVD) or type 1 and type 2 diabetes were enrolled. Plaque Control Record (PCR) and Bleeding on Probing (BOP) were assessed at baseline and after two weeks of PM or positive control treatment in intervention group (IG) and control group (CG). Food intake was estimated by 3-day diet record.
BOP was significantly reduced in all treatments and samples, except for IG in CVD sample (p=0.15). PCR decreased significantly in all treatments and samples (p<0.01). No significance was obtained for BOP and IP in the time x group interaction. Food intake was not significantly different between IG and CG in all samples. Nutrients such as fats and simple carbohydrates were correlated with BOP in patients who received positive control, rather than PM, indicating a lack of food influence on BOP and PCR in IG.
PM treatment was effective in relation to the reduction of PCR and BOP. Probiotics represent a good, but additional, tool for prophylaxis, because they cannot completely substitute the classic oral hygiene methods. Moreover, one week of treatment was not sufficient to draw firm conclusions about the efficacy of the treatment itself.
评估使用 Biocult strong®溶解于中性漱口水中的新型益生菌漱口水（PM）的效果。
共纳入 42 名患有心血管疾病（CVD）或 1 型和 2 型糖尿病的患者。在干预组（IG）和对照组（CG）中，在基线时以及使用 PM 或阳性对照治疗两周后，评估菌斑控制记录（PCR）和探诊出血（BOP）。通过 3 天饮食记录估计食物摄入量。
除 CVD 样本中的 IG（p=0.15）外，所有治疗和样本中的 BOP 均显著降低。所有治疗和样本中的 PCR 均显著降低（p<0.01）。在时间 x 组相互作用方面，BOP 和 IP 没有显著性。在所有样本中，IG 和 CG 之间的食物摄入量没有显著差异。在接受阳性对照的患者中，脂肪和简单碳水化合物等营养素与 BOP 相关，而与 PM 无关，这表明 IG 中的 BOP 和 PCR 不受食物影响。
PM 治疗在降低 PCR 和 BOP 方面有效。益生菌是一种很好的，但额外的预防工具，因为它们不能完全替代经典的口腔卫生方法。此外，一周的治疗不足以对治疗本身的疗效得出确切结论。
