蛙皮素+氟哌啶醇对大鼠苯丙胺诱导的运动刻板行为的影响。
Effects of caerulein + haloperidol on amphetamine-induced locomotor stereotypy in rats.
作者信息
Mueller K, Peel J L, Rewey K L
机构信息
Department of Psychology, Texas Christian University, Fort Worth 76129.
出版信息
Life Sci. 1989;44(11):717-24. doi: 10.1016/0024-3205(89)90383-4.
The combination of haloperidol + caerulein has been reported to produce a long-lasting reduction of amphetamine-induced hyperlocomotions in rats. This study was designed to replicate those findings and to determine whether haloperidol + caerulein produce any unique effect on amphetamine-induced locomotor stereotypy. In two experiments, haloperidol + caerulein failed to produce a long-lasting reduction in amphetamine-induced hyperlocomotions. Although haloperidol reduced the locomotor stereotypy produced by higher doses of amphetamine, caerulein had no effect, either alone or combined with haloperidol.
据报道，氟哌啶醇+蛙皮素的组合可使大鼠体内苯丙胺诱导的运动亢进长期减轻。本研究旨在重复这些发现，并确定氟哌啶醇+蛙皮素是否对苯丙胺诱导的运动刻板行为产生任何独特作用。在两项实验中，氟哌啶醇+蛙皮素未能使苯丙胺诱导的运动亢进长期减轻。尽管氟哌啶醇可减轻高剂量苯丙胺产生的运动刻板行为，但蛙皮素单独或与氟哌啶醇联合使用均无效果。
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