Hashimoto M, Hirai T, Oguchi K, Yasuhara H
Jpn J Pharmacol. 1986 May;41(1):127-30. doi: 10.1254/jjp.41.127.
To elucidate the mechanism of the antagonistic effect of caerulein on amphetamine-induced hyperactivity, monoamine contents in rat brain regions were measured by HPLC. With a combination of caerulein and haloperidol, dopamine contents in methamphetamine treated-rats were significantly decreased in the striatum. Noradrenaline contents were significantly decreased in the haloperidol-methamphetamine group, but caerulein restored it to the normal levels. Serotonin contents did not change in any of the groups tested. These results may indicate that caerulein acts as a neuromodulator in rat brain and causes suppression of hyperactivity induced by methamphetamine.
为阐明蛙皮素对苯丙胺诱导的多动的拮抗作用机制，采用高效液相色谱法测定大鼠脑区单胺含量。联合使用蛙皮素和氟哌啶醇后，甲基苯丙胺处理大鼠纹状体中的多巴胺含量显著降低。氟哌啶醇 - 甲基苯丙胺组去甲肾上腺素含量显著降低，但蛙皮素将其恢复至正常水平。在所测试的任何组中，血清素含量均未发生变化。这些结果可能表明蛙皮素在大鼠脑中起神经调节剂的作用，并抑制甲基苯丙胺诱导的多动。
