重新审视毛囊免疫赦免：斑秃治疗的关键
Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management.
作者信息
Paus Ralf, Bulfone-Paus Silvia, Bertolini Marta
机构信息
Centre for Dermatology Research, University of Manchester, NIHR Manchester Biomedical Research Centre and MAHSC, Manchester, UK.
Centre for Dermatology Research, University of Manchester, NIHR Manchester Biomedical Research Centre and MAHSC, Manchester, UK.
出版信息
J Investig Dermatol Symp Proc. 2018 Jan;19(1):S12-S17. doi: 10.1016/j.jisp.2017.10.014.
The collapse of the immune privilege (IP) of the anagen hair bulb is now accepted as a key element in AA pathogenesis, and hair bulb IP restoration lies at the core of AA therapy. Here, we briefly review the essentials of hair bulb IP and recent progress in understanding its complexity. We discuss open questions and why the systematic dissection of hair bulb IP and its pharmacological manipulation (including the clinical testing of FK506 and α-melanocyte-stimulating hormone analogs) promise to extend the range of future therapeutic options in AA and other IP collapse-related autoimmune diseases.
生长期毛囊球部免疫赦免（IP）的崩溃现已被公认为斑秃（AA）发病机制中的关键因素，而毛囊球部IP的恢复是AA治疗的核心。在此，我们简要回顾毛囊球部IP的要点以及在理解其复杂性方面的最新进展。我们讨论了悬而未决的问题，以及为何对毛囊球部IP进行系统剖析及其药理操作（包括FK506和α-黑素细胞刺激素类似物的临床试验）有望扩展AA及其他与IP崩溃相关的自身免疫性疾病未来的治疗选择范围。
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