Department of Dermatology, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 03312, Republic of Korea.
Int J Mol Sci. 2024 Aug 26;25(17):9236. doi: 10.3390/ijms25179236.
Recent studies have highlighted the potential of Mesenchymal Stem Cells (MSCs) as an alternative treatment for Alopecia Areata (AA) due to their immunosuppressive properties. While MSCs have shown promise in cell experiments, their effectiveness in vivo remains uncertain. This study aims to validate local administration of MSC therapy's efficacy in AA treatment through animal experiments. AA was induced through Interferon-gamma (IFN-γ) administration in mice, and MSC treatment (MSCT)'s effects were assessed visually and through tissue analysis. The MSC-treated group showed more hair regrowth compared to the control (CTL) group. MSCT notably reduced local inflammatory cytokines (JAK1, JAK2, STAT1, STAT3, IFN-γR, IL-1β, IL-16, IL-17α, and IL-18) in AA-induced mice's skin, but systemic cytokine levels remained unchanged. Furthermore, MSC treatment normalized the expression of Wnt/β-catenin signaling pathway genes (LEF1 and β-catenin) and growth factors (FGF7 and FGF2), which are crucial for hair cycle regulation. This study lays the groundwork for further exploring MSCs as a potential treatment for AA, but more research is needed to fully understand their therapeutic potential.
最近的研究强调了间充质干细胞（MSCs）作为斑秃（AA）替代治疗方法的潜力，因为它们具有免疫抑制特性。虽然 MSCs 在细胞实验中表现出了前景，但它们在体内的有效性仍然不确定。本研究旨在通过动物实验验证局部给予 MSC 治疗 AA 的疗效。通过在小鼠中给予干扰素-γ（IFN-γ）诱导 AA，并通过组织分析和肉眼观察评估 MSC 治疗（MSCT）的效果。与对照组（CTL）相比，MSC 治疗组的毛发再生更多。MSCT 显著降低了 AA 诱导的小鼠皮肤中的局部炎症细胞因子（JAK1、JAK2、STAT1、STAT3、IFN-γR、IL-1β、IL-16、IL-17α 和 IL-18），但系统细胞因子水平保持不变。此外，MSC 治疗还使 Wnt/β-catenin 信号通路基因（LEF1 和 β-catenin）和生长因子（FGF7 和 FGF2）的表达正常化，这些基因对于毛发生长周期的调节至关重要。本研究为进一步探索 MSCs 作为 AA 的潜在治疗方法奠定了基础，但仍需要更多的研究来充分了解它们的治疗潜力。
