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[帕金森综合征中的自我间歇性导尿与尿潴留]

[Self-intermittent-catheterization and urinary retentions in Parkinsonian syndromes].

作者信息

Savard E, Declemy A, Coindreau V, Babany F, Chesnel C, Charlanes A, Le Breton F, Amarenco G

机构信息

Groupe de recherche clinique en neuro-urologie (GREEN GRC-01 UPMC), Sorbonne universités, 75005 Paris, France; Service de neuro-urologie, hôpital Tenon, AP-HP, 4, rue de la Chine, 75020 Paris, France.

Groupe de recherche clinique en neuro-urologie (GREEN GRC-01 UPMC), Sorbonne universités, 75005 Paris, France; Service de neuro-urologie, hôpital Tenon, AP-HP, 4, rue de la Chine, 75020 Paris, France.

出版信息

Prog Urol. 2018 Dec;28(17):987-992. doi: 10.1016/j.purol.2017.11.004. Epub 2017 Dec 19.

Abstract

INTRODUCTION

Lower urinary tract symptoms are common in Parkinson diseases, especially chronic urinary retention. In case of significant and symptomatic postvoid residual, a specific treatment is necessary in order to empty the bladder and nowadays the gold standard of such neurogenic bladder is based on self-intermittent-catheterizations, if possible at all. We carried out a retrospective study about feasibility and outcomes of self-intermittent-catheterizations in this population.

METHODS

Retrospective study with qualitative and quantitative, clinical and instrumental (urodynamic) assessment, of lower urinary tract symptoms as urinary retention in extrapyramidal syndromes.

RESULTS

Overall, 42 patients with parkinsonian syndrome performing self-intermittent-catheterization were assessed. Twenty-one had idiopathic Parkinson's disease, 17 multiple system atrophy, 1 vascular Parkinson, 1 iatrogenic Parkinson and 2 not yet determined parkinsonian syndromes. All the patients had urinary retention characterized by a postvoiding residual volume more than 150mL. All the patients were symptomatic and reported voiding dysfunction (30/42), overactive bladder syndrome (20/42), stress urinary incontinence (6/42). The cystometry showed detrusor overactivity (15/42), bladder-sphincter dyssynergia (15/42), detrusor underactivity (14/42), sphincter deficiency (4/42) or bladder compliance alteration (3/42). Each patient have learned and well controlled self-intermittent-catheterization technique. Fourteen (33%) stopped self-intermittent-catheterization prematurely in the following months because of functional impact of neurological worsening.

CONCLUSION

Even if one third of the patients had stopped self-intermittent-catheterization because of neurological deterioration, this technique remains the gold standard for the treatment of urinary chronic retention in parkinsonian patients.

LEVEL OF EVIDENCE

摘要

引言

下尿路症状在帕金森病中很常见,尤其是慢性尿潴留。对于有明显症状的排尿后残余尿量,需要进行特定治疗以排空膀胱,目前这种神经源性膀胱的金标准是自我间歇性导尿,只要有可能。我们对该人群中自我间歇性导尿的可行性和结果进行了一项回顾性研究。

方法

对锥体外系综合征中作为尿潴留的下尿路症状进行定性和定量、临床和仪器(尿动力学)评估的回顾性研究。

结果

总体上,对42例进行自我间歇性导尿的帕金森综合征患者进行了评估。21例患有特发性帕金森病,17例患有多系统萎缩,1例患有血管性帕金森病,1例患有医源性帕金森病,2例帕金森综合征类型尚未确定。所有患者均有尿潴留,其排尿后残余尿量超过150mL。所有患者均有症状,并报告有排尿功能障碍(30/42)、膀胱过度活动症(20/42)、压力性尿失禁(6/42)。膀胱测压显示逼尿肌过度活动(15/42)、膀胱括约肌协同失调(15/42)、逼尿肌活动不足(14/42)、括约肌功能不全(4/42)或膀胱顺应性改变(3/42)。每位患者都学会并很好地掌握了自我间歇性导尿技术。14例(33%)在接下来的几个月中由于神经功能恶化的功能影响而提前停止了自我间歇性导尿。

结论

即使三分之一的患者因神经功能恶化而停止了自我间歇性导尿,但该技术仍然是帕金森病患者慢性尿潴留治疗的金标准。

证据级别

4级。

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