Samie M R, Ashton A K
Department of Neurology, State University of New York, Buffalo.
Mov Disord. 1989;4(1):81-4. doi: 10.1002/mds.870040111.
Cyproheptadine is an antihistamine with antiserotoninergic and anticholinergic properties. It is a relatively safe drug with many varied indications for usage, which rarely produces serious adverse neurologic sequelae. Reports of involuntary movement disorder secondary to cyproheptadine are rare. We present the case of a 17-year-old overdose victim which may be the first documented instance of cyproheptadine intoxication resulting in choreoathetosis. This hyperkinesia was most likely resultant from the anticholinergic properties of cyproheptadine. Although the choreoathetoid movement resolved spontaneously, the delirious state disappeared after administration of physostigmine.
赛庚啶是一种具有抗血清素能和抗胆碱能特性的抗组胺药。它是一种相对安全的药物，有多种不同的使用适应症，很少产生严重的不良神经后遗症。继发于赛庚啶的不自主运动障碍的报告很少见。我们报告一例17岁的过量服药受害者，这可能是赛庚啶中毒导致舞蹈手足徐动症的首个有记录病例。这种运动亢进很可能是由赛庚啶的抗胆碱能特性引起的。尽管舞蹈手足徐动样运动自行缓解，但在使用毒扁豆碱后谵妄状态消失。
